甲氧虫酰肼

Description

Methoxyfenozide · CAS 161050-58-4 · C22H28N2O3. UNII 62A22651ZX. Melting Point: 206.2 - 208 °C; Melting Point: MP: 204 - 20.6 °C /Technical/; Solubility: In water, 3.3 mg/L at 20 °C.

Identification

CAS Registry Number	161050-58-4
PubChem CID	105010
Molecular formula	C22H28N2O3
IUPAC name	N'-tert-butyl-N'-(3,5-dimethylbenzoyl)-3-methoxy-2-methylbenzohydrazide
UNII (FDA)	62A22651ZX

Computed Descriptors

Molecular Weight	368.5
XLogP3	4.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Exact Mass	368.20999276
Monoisotopic Mass	368.20999276
Topological Polar Surface Area	58.6
Heavy Atom Count	27
Formal Charge	0

Physical & Chemical Properties

Melting Point	206.2 - 208 °C
Melting Point	MP: 204 - 20.6 °C /Technical/
Solubility	In water, 3.3 mg/L at 20 °C

Physical description & handling notes

• White powder
• In DMSO 11, cyclohexanone 9.9, acetone 9 (all in g/100g at 20 °C)
• log Kow = 3.7 (shake flask)
• When heated to decomposition it emits toxic vapors of /nitrogen oxides/.
• 201.9 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID3032628]
• 194.2 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID3032628]

GHS Hazard Classification

Reported hazard statements	H400 (69.9%), H410 (69.9%), H411 (30.1%), H401

Documented Uses

• The dermal absorption in vivo of methoxyfenozide formulated as an aqueous flow-able liquid (RH-112,485 2F) or as a wettable powder (RH-112,485 280WP) was tested in rats in a study that was designed to comply with US EPA guidelines and GLP. The methoxyfenozide administered was uniformly labelled with (14)C on the methoxyphenyl ring; this is acceptable given the limited cleavage seen in studies of oral metabolism. To provide data on exposure to the concentrated product and in-use-dilutions, groups of four male Crl :
• Two metabolites, M16 (A-ring glucuronide of M14) and M26 (A-ring glucuronide of M24), were the main metabolites in bile. M16 was present at 13% and 18% in males and females respectively, M26 was present at 5% in males and 11% in females, all other metabolites represented <3% of the administered dose. The presence of M16 and M26 at higher concentrations in bile than in feces indicates that these two metabolites were subject to subsequent hydrolysis.
• The primary /metabolic/ pathway probably involves demethylation of the A-ring methoxy moiety to form the corresponding phenol (M14), which is conjugated with glucuronic acid to form M16. Hydroxylation on the B-ring methyl moieties is also a significant metabolic pathway. Cleavage of methoxyfenozide to release either of the rings or the t-butyl group is only a minor pathway; none of the cleaved metabolites (M06, M07, M13, M32-36) were present at >2% of the dose. In males, however, cleaved metabolites represented up
• Results for the animals receiving diets containing methoxyfenozide for 14 days plus a single dose of (14C) methoxyfenozide at 10 mg/kg bw by gavage showed evidence of induction of metabolism. Concentrations of M22, M28 and M30 increased, while concentrations of M14 and M24 were reduced relative to concentrations in animals that received only a single dose of (14C) methoxyfenozide at 10 mg/kg bw.

Synonyms

Methoxyfenozide; 161050-58-4; Intrepid; N'-tert-Butyl-N'-(3,5-dimethylbenzoyl)-3-methoxy-2-methylbenzohydrazide; Runner; 3-Methoxy-2-methylbenzoic acid 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide; Benzoic acid, 3-methoxy-2-methyl-, 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide; RH-2485; DTXSID3032628; N'-(tert-butyl)-N'-(3,5-dimethylbenzoyl)-3-methoxy-2-methylbenzohydrazide; N-tert-butyl-N'-(3-methoxy-o-toluoyl)-3,5-xylohydrazide; 62A22651ZX; DTXCID1012628; CHEBI:38449; RH-112485; RefChem:157081

Frequently Asked Questions

What are the CAS number and molecular formula of Methoxyfenozide?

CAS 161050-58-4; molecular formula C22H28N2O3; molecular weight — g/mol.

What other names is Methoxyfenozide known by?

Methoxyfenozide, 161050-58-4, Intrepid, N'-tert-Butyl-N'-(3,5-dimethylbenzoyl)-3-methoxy-2-methylbenzohydrazide, Runner, 3-Methoxy-2-methylbenzoic acid 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide.

Is Methoxyfenozide classified as hazardous?

Hazard statements reported: H400, H410, H411, H401.

What are the key physical properties of Methoxyfenozide?

Melting Point: 206.2 - 208 °C; Melting Point: MP: 204 - 20.6 °C /Technical/; Solubility: In water, 3.3 mg/L at 20 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.