甲硝唑

Description

2-Methyl-5-nitroimidazole-1-ethanol · CAS 443-48-1 · C6H9N3O3. UNII 140QMO216E. Boiling Point: 405.4; Melting Point: 316 to 320 °F (NTP, 1992); Melting Point: 160.

Identification

CAS Registry Number	443-48-1
PubChem CID	4173
Molecular formula	C6H9N3O3
IUPAC name	2-(2-methyl-5-nitroimidazol-1-yl)ethanol
UNII (FDA)	140QMO216E

Computed Descriptors

Molecular Weight	171.15
XLogP3	0
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	171.06439116
Monoisotopic Mass	171.06439116
Topological Polar Surface Area	83.9
Heavy Atom Count	12
Formal Charge	0

Physical & Chemical Properties

Boiling Point	405.4
Melting Point	316 to 320 °F (NTP, 1992)
Melting Point	160
Melting Point	158-160 °C
Melting Point	160 °C
Solubility	In water, 11,000 mg/L at 25 °C
Solubility	5.92e+00 g/L
LogP	-0.02
LogP	log Kow = -0.02
LogP	-0.1

Physical description & handling notes

• Metronidazole is a white to pale-yellow crystalline powder with a slight odor. Bitter and saline taste. pH (saturated aqueous solution) about 6.5. (NTP, 1992)
• Solid
• Cream-colored crystals
• WHITE TO PALE YELLOW CRYSTALS OR CRYSTALLINE POWDER
• ODORLESS
• less than 1 mg/mL at 68 °F (NTP, 1992)

Regulatory Status

Regulatory & Food Contact	ANTIPROTOZOAL_AGENT: Veterinary Drug FLAGYL ADI NOT EVALUATED Relevant toxicological data were unavailable for the Committee's evaluation. TRS 788-JECFA 34/27
GHS notification summary	1.1% (2 / 177)

GHS Hazard Classification

GHS notification summary	1.1% (2 / 177)
Reported hazard statements	H302 (15.3%), H312 (16.4%), H332 (16.9%), H341 (53.7%), H350 (49.7%), H351 (34.5%), H373 (29.4%), H412 (39.5%)

Documented Uses

• Mesh Heading: Anti-infective agents, antiprotozoal agents, radiation-sensitizing agents
• Topical treatment of inflammatory lesions of rosacea
• For more Uses (Complete) data for METRONIDAZOLE (8 total), please visit the HSDB record page.
• Use (kg) in Switzerland (2009): >1000
• Use (kg; approx.) in Germany (2009): >10000
• Use (kg; exact) in Germany (2009): 12354

Synonyms

metronidazole; 443-48-1; Metronidazol; Gineflavir; 2-Methyl-5-nitroimidazole-1-ethanol; Deflamon; Orvagil; Trichazol; MetroGel; Sanatrichom; Anagiardil; Danizol; Meronidal; Metronidaz; Mexibol; Trichocide

Frequently Asked Questions

What are the CAS number and molecular formula of 2-Methyl-5-nitroimidazole-1-ethanol?

CAS 443-48-1; molecular formula C6H9N3O3; molecular weight — g/mol.

What other names is 2-Methyl-5-nitroimidazole-1-ethanol known by?

metronidazole, 443-48-1, Metronidazol, Gineflavir, 2-Methyl-5-nitroimidazole-1-ethanol, Deflamon.

What is the regulatory status of 2-Methyl-5-nitroimidazole-1-ethanol?

Documented regulatory listings: ANTIPROTOZOAL_AGENT: Veterinary Drug; FLAGYL; ADI NOT EVALUATED.

Is 2-Methyl-5-nitroimidazole-1-ethanol classified as hazardous?

1.1% of GHS notifications report no hazard classification (2 of 177).

What are the key physical properties of 2-Methyl-5-nitroimidazole-1-ethanol?

Boiling Point: 405.4; Melting Point: 316 to 320 °F (NTP, 1992); Melting Point: 160; Melting Point: 158-160 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.