Tebufenozide

Description

Tebufenozide · CAS 142583-69-5 · C22H28N2O2. UNII TNN5MI5EKF. Melting Point: 191 °C; Solubility: In water, 0.83 mg/l @ 25 °C; Vapor Pressure: 0.00000002 [mmHg].

Identification

CAS Registry Number	142583-69-5
PubChem CID	91773
Molecular formula	C22H28N2O2
IUPAC name	N-tert-butyl-N'-(4-ethylbenzoyl)-3,5-dimethylbenzohydrazide
UNII (FDA)	TNN5MI5EKF

Computed Descriptors

Molecular Weight	352.5
XLogP3	3.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	4
Exact Mass	352.215078140
Monoisotopic Mass	352.215078140
Topological Polar Surface Area	49.4
Heavy Atom Count	26
Formal Charge	0

Physical & Chemical Properties

Melting Point	191 °C
Solubility	In water, 0.83 mg/l @ 25 °C
Vapor Pressure	0.00000002 [mmHg]
Vapor Pressure	2.25X10-8 mm Hg @ 25 °C
LogP	4.25
Ionization Efficiency	2.27
Ionization Efficiency	2.7
Ionization Efficiency	MeCN (80%)
Ionization Efficiency	DOI:10.1038/s41598-020-62573-z
Collision Cross Section	202.78 Ų [M+Na]+

Physical description & handling notes

• Off-white solid; [HSDB] Off-white powder; [MSDSonline]
• Off-white powder
• Slightly soluble in organic solvents
• 1.03 (20 °C, pycrometer method)
• log Kow= 4.25 (pH 7)
• Stable at 94 °C for 7 days. Stable to light in pH 7 aq soln, (25 °C). Stable in dark, sterile water 30 days, (25 °C). DT50 in natural pond water, in light, 30 days (25 °C).

GHS Hazard Classification

Reported hazard statements	H411, H400 (31.5%), H410 (31.5%), H336, H361, H372, H373

Documented Uses

• Used as insecticide for control of lepidopteron larvae on rice, fruit, row crops, nut crops, vegetables, vines, and forestry; [HSBD]
• Control of lepidopteran larvae on rice, fruit, row crops, nut crops, vegetables, vines, and forestry.
• A.C. Hsu, H. E. Allen, AU 64289; eidem, US 4985461 (1986, 1991 both to Rohm & Haas)
• Mode of action: Ecdysone agonist which acts by binding to the ecdysone receptor protein. The molting process is lethally accelerated.
• The absorption, distribution, excretion and metabolism of tebufenozide in rats was investigated. Tebufenozide is partially absorbed, is rapidly excreted and does not accumulate in tissues. Although tebufenozide is mainly excreted unchanged, a number of polar metabolites were identified.
• In the rat, 16 whole-molecule metabolites are formed as a result of oxidation of the alkyl substituents of the aromatic rings, primarily at the benzylic positions.

Synonyms

Tebufenozide; 112410-23-8; N-tert-Butyl-N'-(4-ethylbenzoyl)-3,5-dimethylbenzohydrazide; Confirm; RH-5992; Mimic; DTXSID4034948; TNN5MI5EKF; N'-(t-Butyl)-N'-(3,5-dimethylbenzoyl)-N-(4-ethylbenzoyl)hydrazine; 3,5-Dimethylbenzoic acid 1-(1,1-dimethylethyl)-2-(4-ethylbenzoyl)hydrazide; CHEBI:38452; DTXCID2014948; RH5992; RefChem:187654; 412-850-3; 601-185-6

Frequently Asked Questions

What are the CAS number and molecular formula of Tebufenozide?

CAS 142583-69-5; molecular formula C22H28N2O2; molecular weight — g/mol.

What other names is Tebufenozide known by?

Tebufenozide, 112410-23-8, N-tert-Butyl-N'-(4-ethylbenzoyl)-3,5-dimethylbenzohydrazide, Confirm, RH-5992, Mimic.

Is Tebufenozide classified as hazardous?

Hazard statements reported: H411, H400, H410, H336, H361.

What are the key physical properties of Tebufenozide?

Melting Point: 191 °C; Solubility: In water, 0.83 mg/l @ 25 °C; Vapor Pressure: 0.00000002 [mmHg]; Vapor Pressure: 2.25X10-8 mm Hg @ 25 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.