尼美舒利

尼美舒利（CAS 1364966-82-4）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

法规与备案状态

物理形态与操作说明

• 165.8 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID3037250]
• 167.29 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 160.45 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 165.63 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• Food, gender and advanced age have negligible effects on nimesulide pharmacokinetics.

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
• Nimesulide is a nonsteroidal antiinflammatory drug (NSAID) with relative specificity for COX-2 that is not available in the United States, but is used widely in other countries in the treatment of acute pain. Nimesulide has been linked to a low rate of transient serum enzyme elevations during therapy, but also to many instances of clinically apparent acute liver injury that can be severe and can result in acute liver failure, need for emergency liver transplantation and death.
• Nonsteroidal Antiinflammatory Drugs
• Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
• Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
• M01 - Antiinflammatory and antirheumatic products

它在各数据库里的别名

nimesulide; 51803-78-2; N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide; Aulin; R-805; Nimesulida; 4-NITRO-2-PHENOXYMETHANESULFONANILIDE; Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)-; Nimesulidum; R 805; 4'-Nitro-2'-phenoxymethanesulfonanilide; DTXSID3037250; NSC-758412; V4TKW1454M; DTXCID1017250; CHEBI:44445

计算机算出的分子描述符

数据库摘要

Nimesulide · CAS 1364966-82-4 · C13H12N2O5S. UNII V4TKW1454M. 熔点: 143-144.5 °C; LogP: 2.6; LogP: 1.99.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。