Olmesartan

Description

Olmesartan · CAS 144689-24-7 · C24H26N6O3. UNII 8W1IQP3U10. Boiling Point: 800; Melting Point: 177.6; Melting Point: 175 - 180 °C.

Identification

CAS Registry Number	144689-24-7
PubChem CID	158781
Molecular formula	C24H26N6O3
IUPAC name	5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
UNII (FDA)	8W1IQP3U10

Computed Descriptors

Molecular Weight	446.5
XLogP3	3.2
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	8
Exact Mass	446.20663871
Monoisotopic Mass	446.20663871
Topological Polar Surface Area	130
Heavy Atom Count	33
Formal Charge	0

Physical & Chemical Properties

Boiling Point	800
Melting Point	177.6
Melting Point	175 - 180 °C
Solubility	1.05e-02 g/L
LogP	0.73
LogP	5.9
Dissociation Constants	4.3

Physical description & handling notes

• Solid
• Insoluble
• Soluble to 20 mM in DMSO
• White to light yellowish-powder or crystalline powder. It is practically insoluble in water and sparingly soluble in methanol /Olmesartan medoxomil/
• Table: Olmesartan Medoxomil Preparations [Table#8198]
• Table: Olmesartan Medoxomil Combination Preparations [Table#8199]

Regulatory Status

GHS notification summary	33.3% (1 / 3)

GHS Hazard Classification

GHS notification summary	33.3% (1 / 3)
Reported hazard statements	H302 (66.7%), H312 (66.7%), H315 (33.3%), H319 (33.3%), H332 (66.7%), H335 (33.3%)

Documented Uses

• Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents
• Preparation: H. Yanagisawa et al., European Patent Office patent 503785; eidem, United States of America patent 5616599 (1992, 1997 both to Sankyo).
• Olmesartan is an angiotensin II receptor blocker used in the therapy of hypertension. Olmesartan is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of acute liver injury.
• Breast Feeding; Lactation; Milk, Human; Antihypertensive Agents; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Blockers; ARBs
• Angiotensin II Receptor Antagonists
• Both angiotensin II receptor antagonists /including olmesartan/ and ACE inhibitors have been shown to slow the rate of progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy, and use of a drug from either class is recommended in such patients. /NOT included in US product label/

Synonyms

Olmesartan; 144689-24-7; RNH-6270; omesartan; NSC-759810; 8W1IQP3U10; DTXSID2040571; CHEBI:48416; olmesartanum; olmesartanum medoxomilum; RefChem:55770; DTXCID0020571; Olmesartan Acid; 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid; CS-088; MFCD00914967

Frequently Asked Questions

What are the CAS number and molecular formula of Olmesartan?

CAS 144689-24-7; molecular formula C24H26N6O3; molecular weight — g/mol.

What other names is Olmesartan known by?

Olmesartan, 144689-24-7, RNH-6270, omesartan, NSC-759810, 8W1IQP3U10.

Is Olmesartan classified as hazardous?

33.3% of GHS notifications report no hazard classification (1 of 3).

What are the key physical properties of Olmesartan?

Boiling Point: 800; Melting Point: 177.6; Melting Point: 175 - 180 °C; Solubility: 1.05e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.