Description
fluticasone · CAS 90566-53-3 · C22H27F3O4S. UNII CUT2W21N7U.
Identification
| CAS Registry Number | 90566-53-3 |
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| PubChem CID | 5311101 |
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| Molecular formula | C22H27F3O4S |
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| IUPAC name | S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carbothioate |
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| UNII (FDA) | CUT2W21N7U |
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Computed Descriptors
| Molecular Weight | 444.5 |
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| XLogP3 | 3.2 |
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| Hydrogen Bond Donor Count | 2 |
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| Hydrogen Bond Acceptor Count | 8 |
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| Rotatable Bond Count | 3 |
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| Exact Mass | 444.15821500 |
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| Monoisotopic Mass | 444.15821500 |
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| Topological Polar Surface Area | 99.9 |
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| Heavy Atom Count | 30 |
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| Formal Charge | 0 |
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Physical description & handling notes
- Crystals. MW 500.57. MP 272-273 °C (decomposes). Specific optical rotation: +30 deg at 25 °C/D (c = 0.35). Practically insolluble in water. Freely soluble in dimethylsulfoxide, dimethyl formate; slightly soluble in methanol, 95% ethanol. /Fluticasone propionate/
- Systemically, in vitro experiments show [DB08906] activates glucocorticoid receptors, inhibits nuclear factor kappa b, and inhibits lung eosinophilia in rats. [DB00588] performs similar activity but is not stated to affect nuclear factor kappa b. [DB00588] as a topical formulation is also associated with vasoconstriction in the skin.
- Each gram of fluticasone propionate cream contains fluticasone propionate 0.5 mg in a base of propylene glycol, mineral oil, cetostearyl alcohol, Ceteth-20, isopropyl myristate, dibasic sodium phosphate, citric acid, purified water, and imidurea as preservative. /Fluticasone propionate/
- Each gram of fluticasone propionate ointment contains fluticasone propionate 0.05 mg in a base of liquid paraffin, microcrystalline wax, propylene glycol, and sorbitan sesquioleate. /Fluticasone propionate/
- Fluticasone propionate HFA inhalation aerosols (44, 110, 220 ug) are pressurized metered-dose aerosol units fitted with a counter. ... Each unit contains a microcrystalline suspension of fluticasone propionate (micronized) in propellant HFA-134a (1,1,1,2-tetrafluoroethane). It contains no other excipients. /Fluticasone propionate/
GHS Hazard Classification
| Reported hazard statements | H302 (100%), H312 (100%), H315 (100%), H319 (100%), H332 (100%) |
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H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
Documented Uses
- Relieve inflammatory and pruritic symptoms of dermatoses and psoriases, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma /Fluticasone propionate/
- Fluticasone propionate is claimed to exert a topical effect on the lungs without significant systemic effects, due to its low systemic bioavailability. /Fluticasone propionate/
- THERAP CAT: Antiallergic; antiasthmatic; anti-inflammatory /Fluticasone propionate/
- Use (kg; approx.) in Germany (2009): >75
- Consumption (g per capita; approx.) in Germany (2009): 0.000916
- 6alpha,9-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17-propanoyloxy)androsta-1,4-diene-17beta-carboxylic acid
Synonyms
fluticasone; 90566-53-3; Fluticasona; Fluticasonum; Fluticaps; Optinose; CUT2W21N7U; Opn-375; CHEBI:5134; DTXSID0044022; HFA, Flovent; Propionate, Fluticasone; RefChem:55221; DTXCID60820064; Flunase; Fluticaps (TN)
Frequently Asked Questions
What are the CAS number and molecular formula of fluticasone?
CAS 90566-53-3; molecular formula C22H27F3O4S; molecular weight — g/mol.
What other names is fluticasone known by?
fluticasone, 90566-53-3, Fluticasona, Fluticasonum, Fluticaps, Optinose.
Is fluticasone classified as hazardous?
Hazard statements reported: H302, H312, H315, H319, H332.
Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.
