泊马度胺

泊马度胺（CAS 19171-19-8）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• Solid yellow powder
• Limited to low solubility into organic solvents ... low solubility in all pH solutions (about 0.01 mg/mL)
• Stable under recommended storage conditions.
• Pomalidomide is more potent than thalidomide (100-times) and lenalidomide (10-times).
• Table: Pomalidomide Preparations [Table#8206]

这个物质在各数据库里的编号

数据库记载的用途

• Angiogenesis Inhibitors; Immunologic Factors
• Pomalidomide is synthesized in two main steps using commercially available well defined starting materials with acceptable specifications. The first step consists of a coupling reaction in which the starting materials react to form crude pomalidomide. The second step is a purification process consisting on filtration, crystallization and drying to obtain the final drug substance.
• Preparation: G. W. Muller et al., World Intellectual Property Organization patent 9803502; eidem, United States of America patent 6335349 (1998, 2002 both to Celgene).
• Pomalidomide is indicated for patients with multiple myeloma who have received at least two prior therapies including lenalidomide and have demonstrated disease progression on or within 60 days of completion of the last therapy. It is also indicated for the treatment of Kaposi's sarcoma (KS) in AIDS patients who have failed highly active antiretroviral therapy (HAART) and for the treatment of KS in HIV-negative patients.
• Pomalidomide is an immunomodulatory and antineoplastic agent that is used in the therapy of multiple myeloma. Pomalidomide, like the structurally related agents thalidomide and lenalidomide, is associated with a low rate of serum aminotransferase elevations during therapy and has been implicated in causing rare instances of clinically apparent liver injury which can be severe.
• Breast Feeding; Lactation; Milk, Human; Immunosuppressive Agents; Angiogenesis Inhibitors

它在各数据库里的别名

Pomalidomide; 19171-19-8; Actimid; Pomalyst; CC-4047; Imnovid; 4-Aminothalidomide; 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-; 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; IMID-3; 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide; IMiD 3; CC 4047; Pomalidomida; D2UX06XLB5

计算机算出的分子描述符

数据库摘要

Pomalidomide · CAS 19171-19-8 · C13H11N3O4. UNII D2UX06XLB5.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。