苯甲酸利扎曲普坦

Description

Rizatriptan Benzoate · CAS 145202-66-0 · C15H19N5. UNII 51086HBW8G. Melting Point: 178-180; Melting Point: 178 - 180 °C; Solubility: 42.

Identification

CAS Registry Number	145202-66-0
PubChem CID	5078
Molecular formula	C15H19N5
IUPAC name	N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
UNII (FDA)	51086HBW8G

Computed Descriptors

Molecular Weight	269.34
XLogP3	1.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	269.16404563
Monoisotopic Mass	269.16404563
Topological Polar Surface Area	49.7
Heavy Atom Count	20
Formal Charge	0

Physical & Chemical Properties

Melting Point	178-180
Melting Point	178 - 180 °C
Solubility	42
Solubility	3.38e-01 g/L
LogP	1.4

Physical description & handling notes

• Solid
• 160.3 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]

GHS Hazard Classification

Reported hazard statements	H319 (100%), H336 (100%), H361 (100%), H372 (100%)

Documented Uses

• Rizatriptan is used to treat acute migraine attacks. It does not prevent future migraine attacks. [Wikipedia]
• Breast Feeding; Lactation; Milk, Human; Serotonin Receptor Agonists; Serotonin 5-HT1 Receptor Agonists; Triptans; Vasoconstrictor Agents
• Rizatriptan (Class: Other Substances, Added Date: 09-2003)
• Take with or without food. Food has no significant effect on the bioavailability of rizatriptan but delays the time to reach peak concentration by an hour.
• Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.
• Mechanisms of Action [MoA] - Serotonin 1b Receptor Agonists

Synonyms

rizatriptan; 144034-80-0; Risatriptan; MK 462 free base; N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine; rizatriptanum; 1H-Indole-3-ethanamine, N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-; N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine; DTXSID2023565; MK-462 FREE BASE; 51086HBW8G; DTXCID103565; CHEBI:48273; L-705126; N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]-ethanamine; DIMETHYL({2-[5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOL-3-YL]ETHYL})AMINE

Frequently Asked Questions

What are the CAS number and molecular formula of Rizatriptan Benzoate?

CAS 145202-66-0; molecular formula C15H19N5; molecular weight — g/mol.

What other names is Rizatriptan Benzoate known by?

rizatriptan, 144034-80-0, Risatriptan, MK 462 free base, N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine, rizatriptanum.

Is Rizatriptan Benzoate classified as hazardous?

Hazard statements reported: H319, H336, H361, H372.

What are the key physical properties of Rizatriptan Benzoate?

Melting Point: 178-180; Melting Point: 178 - 180 °C; Solubility: 42; Solubility: 3.38e-01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.