吡非尼酮

吡非尼酮（CAS 53179-13-8）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• White solid from hot water
• 102-104 °C; also as MP 103-105 °C from benzene-light petroleum
• Solubule in methanol
• Stable under recommended storage conditions.
• Pirfenidone is a novel agent with anti-inflammatory, antioxidant, and antifibrotic properties. It may improve lung function and reduce the number of acute exacerbations in patients with idiopathic pulmonary fibrosis (IPF).
• Oral: capsules, 267 mg, Esbriet (InterMune)

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• Prepd by phenylation of 5-methyl-2-pyridinone: S.M. Gadekar, United States of American patent 3839364 (1974 to Affiliates Med. Res.).
• By phytochemical rearrangement of N-phenyl-6-methylpyridinium-3-olate.
• Pirfenidone is indicated for the treatment of idiopathic pulmonary fibrosis (IPF). In Canada and Europe, it is approved in adults only.
• Pirfenidone is an orally available pyridinone derivative that inhibits collagen formation and is used to treat idiopathic pulmonary fibrosis. Elevations in serum enzyme levels during pirfenidone therapy are not uncommon, but it has yet to be implicated in cases of clinically apparent liver injury with jaundice.
• Esbriet is indicated for the treatment of idiopathic pulmonary fibrosis (IPF). /Included in US product label/
• Cigarette smoking reduces peak plasma concentrations and systemic exposure to pirfenidone by 32 and 54%, respectively. The manufacturer recommends that patients be encouraged to stop smoking prior to initiation of pirfenidone and to avoid smoking during therapy.

它在各数据库里的别名

PIRFENIDONE; 53179-13-8; Esbriet; Pirespa; AMR-69; Pirfenidona; Pirfenidonum; 5-methyl-1-phenylpyridin-2-one; 2(1H)-Pyridinone, 5-methyl-1-phenyl-; 5-Methyl-1-phenyl-2(1H)-pyridone; AMR 69; DTXSID4045183; D7NLD2JX7U; NSC-748456; DTXCID2025183; CHEBI:32016

计算机算出的分子描述符

数据库摘要

Pirfenidone · CAS 53179-13-8 · C12H11NO. UNII D7NLD2JX7U. 熔点: 109.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。