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Resveratrol

CAS 501-36-0C14H12O3MW 228.24

Resveratrol (CAS 501-36-0) — formula C14H12O3, molecular weight 228.24.

Specifications

CAS Number501-36-0
Molecular FormulaC14H12O3
Molecular Weight228.24
Melting Point254
LogPlog Kow = 3.10
ApplicationsUses: Nutritional supplement, Resveratrol is a pigment from red wine that ... inhibits LDL, low-density lipoprotein, oxidation, Resveratrol is found in red wine, red grape skins, purple grape juice, mulberries, and in smaller amounts in peanuts. It is used as a medicine., Resveratrol dietary supplements available in the U.S. contain extracts of the root of Polygonum cuspidatum, also known as Hu Zhang or kojo-kon. Red wine extracts and red grape extracts containing resveratrol and other polyphenols are also available in the US as dietary supplements. Resveratrol supplements may contain anywhere from 10-50 mg of resveratrol., For more Uses (Complete) data for RESVERATROL (8 total), please visit the HSDB record page., Methods of Manufacturing: Isolated from white hellebore, ... from fescue grass, ... Isolation of monomers, oligomers, isomers and glucosides from wine., Isolation from fresh root of Polygonum cuspidatum., 3-beta-mono-D-glucoside, Resveratrol is produced by grape vines in response to fungal infection and is known to occur in grapes(1). Its presence is also induced by stress, injury or ultraviolet irradiation(2)., Formulations, Preparations: Resveratrol marketed as a nutritional supplements, is typically an extract of Polygonum cuspidatum ... Such an extract contains both cis- and trans-resveratrol. The extracts are usually standardized to deliver ca 8% resveratrol in its various forms. Many of the products currently marketed have resveratrol in combination with other phytonutrients and vitamins. Some supplements deliver 16 milligrams per serving or higher., General Manufacturing Information: Phytoalexin found in a variety of plants, active ingredient of Asian folk medicine "Kojo-Kan" which is the powdered root of the Japanese knotweed., Anti-aging property ... in skin-care formulation, with 17 times greater antioxidant activity than idebenone, Resveratrol occurs in wine(1). When red wine is made, the "must" is used - skins, seeds, and stems. The must is left in the mixture for a long periods of time as the wine ferments and the oliogomeric proanthocyanidins (OPCs) such as resveratrol emerge, giving red wine its characteristic flavor and color. With white wine, the must is taken out early so it neither darkens nor absorbs as many OPCs. Grape juice also contains OPCs but does not confer the same health benefits as red wine(2). The injury to the grape skin, produced during the process of making wine, increases resveratrol levels(1)., Resveratrol is found in grapevines (Vitis vinifera L). It occurs in the wines, roots, seeds and stalks, but its highest concentration is in grape skins. Wine also contains resveratrol. The concentration of resveratrol in red wine is much higher than that of white wine. The main difference between red and white wine production, besides the grapes used, is that for the red wine the skins and seeds are involved in the process, while white wine is mainly prepared from the juice, essentially avoiding the use of grape skins and seeds. During the wine making process, resveratrol, as well as other polyphenols, including quercetin, catechins, gallocatechins, procyanidins and prodelphidins (condensed tannis), are extracted from the grape skins via a process called maceration., In addition to grapes and wine, dietary sources of resveratrol include peanuts and mulberries. Resveratrol is also found in significant amounts in the dried roots and stems of the plant Polygonium cuspidatum Sieb. Et Zucc., also known as the Japanese knotweed... Most of the resveratrol-containing supplements which are marketed in the U.S. contain extracts of the root of Polygonium cuspidatum.

Where it is used

Documented applications: Uses: Nutritional supplement, Resveratrol is a pigment from red wine that ... inhibits LDL, low-density lipoprotein, oxidation, Resveratrol is found in red wine, red grape skins, purple grape juice, mulberries, and in smaller amounts in peanuts. It is used as a medicine., Resveratrol dietary supplements available in the U.S. contain extracts of the root of Polygonum cuspidatum, also known as Hu Zhang or kojo-kon. Red wine extracts and red grape extracts containing resveratrol and other polyphenols are also available in the US as dietary supplements. Resveratrol supplements may contain anywhere from 10-50 mg of resveratrol., For more Uses (Complete) data for RESVERATROL (8 total), please visit the HSDB record page., Methods of Manufacturing: Isolated from white hellebore, ... from fescue grass, ... Isolation of monomers, oligomers, isomers and glucosides from wine., Isolation from fresh root of Polygonum cuspidatum., 3-beta-mono-D-glucoside, Resveratrol is produced by grape vines in response to fungal infection and is known to occur in grapes(1). Its presence is also induced by stress, injury or ultraviolet irradiation(2)., Formulations, Preparations: Resveratrol marketed as a nutritional supplements, is typically an extract of Polygonum cuspidatum ... Such an extract contains both cis- and trans-resveratrol. The extracts are usually standardized to deliver ca 8% resveratrol in its various forms. Many of the products currently marketed have resveratrol in combination with other phytonutrients and vitamins. Some supplements deliver 16 milligrams per serving or higher., General Manufacturing Information: Phytoalexin found in a variety of plants, active ingredient of Asian folk medicine "Kojo-Kan" which is the powdered root of the Japanese knotweed., Anti-aging property ... in skin-care formulation, with 17 times greater antioxidant activity than idebenone, Resveratrol occurs in wine(1). When red wine is made, the "must" is used - skins, seeds, and stems. The must is left in the mixture for a long periods of time as the wine ferments and the oliogomeric proanthocyanidins (OPCs) such as resveratrol emerge, giving red wine its characteristic flavor and color. With white wine, the must is taken out early so it neither darkens nor absorbs as many OPCs. Grape juice also contains OPCs but does not confer the same health benefits as red wine(2). The injury to the grape skin, produced during the process of making wine, increases resveratrol levels(1)., Resveratrol is found in grapevines (Vitis vinifera L). It occurs in the wines, roots, seeds and stalks, but its highest concentration is in grape skins. Wine also contains resveratrol. The concentration of resveratrol in red wine is much higher than that of white wine. The main difference between red and white wine production, besides the grapes used, is that for the red wine the skins and seeds are involved in the process, while white wine is mainly prepared from the juice, essentially avoiding the use of grape skins and seeds. During the wine making process, resveratrol, as well as other polyphenols, including quercetin, catechins, gallocatechins, procyanidins and prodelphidins (condensed tannis), are extracted from the grape skins via a process called maceration., In addition to grapes and wine, dietary sources of resveratrol include peanuts and mulberries. Resveratrol is also found in significant amounts in the dried roots and stems of the plant Polygonium cuspidatum Sieb. Et Zucc., also known as the Japanese knotweed... Most of the resveratrol-containing supplements which are marketed in the U.S. contain extracts of the root of Polygonium cuspidatum..

Purchase Profile

What this product is

Resveratrol is a chemical compound with CAS registry number 501-36-0 and molecular formula C14H12O3 (molecular weight 228.24).

Identification

CAS number: 501-36-0

Its molecular formula C14H12O3 comprises 14 C, 12 H, 3 O atoms.

Also known as: Resveratrol · Collagen

Frequently Asked Questions

What is the CAS number of Resveratrol?

The CAS registry number of Resveratrol is 501-36-0.

What is the molecular formula and molecular weight of Resveratrol?

Molecular formula C14H12O3, molecular weight 228.24.

What other names is Resveratrol known by?

It is also registered under: Resveratrol, Collagen.

What are the documented applications of Resveratrol?

Recorded applications: Uses: Nutritional supplement, Resveratrol is a pigment from red wine that ... inhibits LDL, low-density lipoprotein, oxidation, Resveratrol is found in red wine, red grape skins, purple grape juice, mulberries, and in smaller amounts in peanuts. It is used as a medicine., Resveratrol dietary supplements available in the U.S. contain extracts of the root of Polygonum cuspidatum, also known as Hu Zhang or kojo-kon. Red wine extracts and red grape extracts containing resveratrol and other polyphenols are also available in the US as dietary supplements. Resveratrol supplements may contain anywhere from 10-50 mg of resveratrol., For more Uses (Complete) data for RESVERATROL (8 total), please visit the HSDB record page., Methods of Manufacturing: Isolated from white hellebore, ... from fescue grass, ... Isolation of monomers, oligomers, isomers and glucosides from wine., Isolation from fresh root of Polygonum cuspidatum., 3-beta-mono-D-glucoside, Resveratrol is produced by grape vines in response to fungal infection and is known to occur in grapes(1). Its presence is also induced by stress, injury or ultraviolet irradiation(2)., Formulations, Preparations: Resveratrol marketed as a nutritional supplements, is typically an extract of Polygonum cuspidatum ... Such an extract contains both cis- and trans-resveratrol. The extracts are usually standardized to deliver ca 8% resveratrol in its various forms. Many of the products currently marketed have resveratrol in combination with other phytonutrients and vitamins. Some supplements deliver 16 milligrams per serving or higher., General Manufacturing Information: Phytoalexin found in a variety of plants, active ingredient of Asian folk medicine "Kojo-Kan" which is the powdered root of the Japanese knotweed., Anti-aging property ... in skin-care formulation, with 17 times greater antioxidant activity than idebenone, Resveratrol occurs in wine(1). When red wine is made, the "must" is used - skins, seeds, and stems. The must is left in the mixture for a long periods of time as the wine ferments and the oliogomeric proanthocyanidins (OPCs) such as resveratrol emerge, giving red wine its characteristic flavor and color. With white wine, the must is taken out early so it neither darkens nor absorbs as many OPCs. Grape juice also contains OPCs but does not confer the same health benefits as red wine(2). The injury to the grape skin, produced during the process of making wine, increases resveratrol levels(1)., Resveratrol is found in grapevines (Vitis vinifera L). It occurs in the wines, roots, seeds and stalks, but its highest concentration is in grape skins. Wine also contains resveratrol. The concentration of resveratrol in red wine is much higher than that of white wine. The main difference between red and white wine production, besides the grapes used, is that for the red wine the skins and seeds are involved in the process, while white wine is mainly prepared from the juice, essentially avoiding the use of grape skins and seeds. During the wine making process, resveratrol, as well as other polyphenols, including quercetin, catechins, gallocatechins, procyanidins and prodelphidins (condensed tannis), are extracted from the grape skins via a process called maceration., In addition to grapes and wine, dietary sources of resveratrol include peanuts and mulberries. Resveratrol is also found in significant amounts in the dried roots and stems of the plant Polygonium cuspidatum Sieb. Et Zucc., also known as the Japanese knotweed... Most of the resveratrol-containing supplements which are marketed in the U.S. contain extracts of the root of Polygonium cuspidatum..

PubChem Public Data

Public-database records for Resveratrol (CAS 501-36-0), reproduced here for independent cross-checking.

Safety classification and hazard statements

GHS notification summary0.6% (1 / 160)
Reported hazard statementsH315 (13.8%), H318 (10%), H319 (88.8%), H335 (11.2%)

This chemical does not meet GHS hazard criteria for 0.6% (1 of 160) of reports.

H315 (13.8%): Causes skin irritation [Warning Skin corrosion/irritation]

Regulatory listings

Regulatory & Food ContactIngredient in bottled water products at levels up to 10 milligrams per liter
Scientific procedures
At the notifier's request, FDA ceased to evaluate this notice
ATLA Holdings, LLC
GHS notification summary0.6% (1 / 160)

Physical description and handling notes

  • Solid
  • Off-white powder from methanol
  • In water, 3 mg/100 mL
  • Soluble in organic solvents such as ethanol, DMSO and dimethyl formamide at approximately 65 mg/mL; solubility in PBS (phosphate buffered saline) at pH 7.2 is approximately 100 ug/mL
  • When heated to decomposition it emits acrid smoke and irritating vapors.
  • 159.3 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID4031980]

Reported physical properties

熔点254
熔点253-255 °C
熔点MP: 261 °C (decomposes)
熔点254 °C
LogPlog Kow = 3.10
LogP2.56

How this substance is indexed

CAS Registry Number501-36-0
PubChem CID445154
分子式C14H12O3
IUPAC 名称5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
UNII(FDA)Q369O8926L

Documented uses

  • Resveratrol is a pigment from red wine that ... inhibits LDL /low-density lipoprotein/ oxidation
  • Resveratrol is found in red wine, red grape skins, purple grape juice, mulberries, and in smaller amounts in peanuts. It is used as a medicine.
  • Resveratrol dietary supplements available in the U.S. contain extracts of the root of Polygonum cuspidatum, also known as Hu Zhang or kojo-kon. Red wine extracts and red grape extracts containing resveratrol and other polyphenols are also available in the US as dietary supplements. Resveratrol supplements may contain anywhere from 10-50 mg of resveratrol.
  • For more Uses (Complete) data for RESVERATROL (8 total), please visit the HSDB record page.
  • Isolated from white hellebore; ... from fescue grass; ... Isolation of monomers, oligomers, isomers and glucosides from wine.
  • Isolation from fresh root of Polygonum cuspidatum. /3-beta-mono-D-glucoside/

Names this substance appears under

resveratrol; 501-36-0; trans-resveratrol; 3,4',5-Trihydroxystilbene; (E)-resveratrol; Resvida; 3,4',5-Stilbenetriol; 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol; 3,4',5-Trihydroxy-trans-stilbene; Biofort; Cuspidatin; 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol; Jotrol; SRT-501; (E)-5-(p-Hydroxystyryl)resorcinol; Resveratrol p 5

Computed molecular descriptors

分子量228.24
XLogP33.1
氢键供体数3
氢键受体数3
可旋转键数2
精确质量228.078644241
单同位素质量228.078644241
拓扑极性表面积60.7
重原子数17
形式电荷0

Database abstract

Resveratrol · CAS 501-36-0 · C14H12O3. UNII Q369O8926L. 熔点: 254; 熔点: 253-255 °C; 熔点: MP: 261 °C (decomposes).

Source: PubChem / Wikidata; the batch COA governs where values differ.

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