Fosphenytoin

Public-database records for Fosphenytoin (CAS 93390-81-9), reproduced here for independent cross-checking.

Physical description and handling notes

• Solid
• White crystals from acetone
• Mol wt: 406.24. White crystals as the dihydrate from water-ethanol-acetone, mp 220 °C (softens). pH of a saturated aqueous solution: approx 9. 溶解度 at 25 °C (mg/mL): 142 in water /Disodium salt/
• Cerebyx

Reported physical properties

How this substance is indexed

Documented uses

• Consumption (g per capita) in the USA (2002): 0.000986
• For the control of generalized convulsive status epilepticus and prevention and treatment of seizures occurring during neurosurgery. It can also be substituted, short-term, for oral phenytoin.
• Prepn: V.J. Stella, K.B. Sloan, US 4260769 (1981 to INTERx).
• Marketing status: None (Tentative approval) /Sodium/
• Fosphenytoin is indicated for the treatment of generalized tonic-clonic status epilepticus and for the prevention and treatment of seizures occurring during neurosurgery in adult patients. It can also be substituted, short-term, for oral phenytoin in patients aged two years and older when oral phenytoin administration is not possible.
• Fosphenytoin is a water-soluble prodrug formulation of phenytoin. It received FDA approval in 1996 for use in epilepsy. It is most commonly used in acute scenarios as an anti-epileptic drug (AED) and a substitute for phenytoin when there are contraindications to phenytoin. Initially, its use was as a short-term oral substitute for oral phenytoin. However, it quickly gained acceptance as a prophylactic drug for patients undergoing neurosurgery.

Names this substance appears under

Fosphenytoin; 93390-81-9; Fosfenitoina; Fosphenytoine; (3-Phosphoryloxymethyl)phenytoin; Fosphenytoinum; DTXSID9044299; NP-06; [(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methoxy]phosphonic acid; B4SF212641; ACC-9653; DTXCID7024299; 2,4-Imidazolidinedione, 5,5-diphenyl-3-((phosphonooxy)methyl)-; 2,4-Imidazolidinedione, 5,5-diphenyl-3-((phosphonooxy)methyl)-, (SP-4-2)-; HMPDP; 3-(hydroxymethyl)phenytoin phosphate ester

Computed molecular descriptors

Database abstract

Fosphenytoin · CAS 93390-81-9 · C16H15N2O6P. UNII B4SF212641. 熔点: 173-176.5 °C; 溶解度: 1.45e-01 g/L.

Source: PubChem / Wikidata; the batch COA governs where values differ.