Hydrocortisone (CAS 50-23-7) — formula C21H30O5, molecular weight 362.5; category organic chemicals.
Documented applications: Uses: Medicine (antiinflammatory agent), also used as the acetate and sodium succinate salts, THERAP CAT: Glucocorticoid, THERAP CAT (VET): Glucocorticoid, MEDICATION (VET), MEDICATION, Use (kg, approx.) in Germany (2009): >1000, Use (kg) in USA (2002): 21000, Use (kg) in France (2004): 453, Consumption (g per capita, approx.) in Germany (2009): 0.0122, Consumption (g per capita) in the USA (2002): 0.0744, Consumption (g per capita) in France (2004): 0.0075, Excretion rate: 0.06, Calculated removal (%): 45.9, Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients, Pharmaceuticals -> Hormones -> Steroid hormones, Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Household Products: Information on 6 consumer products that contain Hydrocortisone in the following categories is provided:, • Personal Care, • Pet Care, Methods of Manufacturing: ISOLATION FROM ADRENAL GLANDS, Preparation by microbioal transformation: H.C. Murrary, D.H. Perterson, US 2602769 (1952 to Upjohn), Formulations, Preparations: Ointment: 0.5% Cortizone-5, (Pfizer), 1% Cortizone-10, HydroSKIN, (Rugby), 2.5% Hytone, (Dermik). Pledgets (saturated with solution): 0.5% Massengill Medicated Soft Cloth Towelette (with parabens and propylene glycol), (GlaxoSmithKline). Solution: 1% Cortaid FastStick Maximum Strength (with alcohol and methylparaben), Cortaid Spray Maximum Strength (with alcohol and methylparaben), Cortizone-10 Scalp Itch Formula Liquid (with alcohol SD 40-2 60% v, v, benzyl alcohol, and propylene glycol), Penecort (with alcohol SD 40-2 57%, (Allergan), Texacort (with SD alcohol 33% and propylene glycol), (Sirius), 2.5% Texacort, (Sirius)., Lotion: 0.5% HydroSKIN, (Rugby). 1% Ala-Cort, (Del-Ray), Aquanil HC (with benzyl alcohol), (Person & Covey), Cetacort (with parabens), (Healthpoint), Dermacort (with benzyl alcohol), (Solvay) HydroSKIN, (Rugby) LactiCare-HC, (Stiefel) Nutracort (with parabens), Sarnol HC, (Stiefel), 2% Ala-Scalpt, 2.5% Hydrocortisone Lotion, (Glades), Hydrocortisone Lotion, (Major), Hytone (with propylene glycol), (Dermik), LactiCare-HC, Nutracort (with parabens), ProctoCream-HC (with benzyl alcohol), (Physicians Total Care)., Topical: Cream: 0.5% Cortizone-5 (with aloe and parabens), Cortizone for Kids ( with aloe and parabens), 1% Ala-Cort, Cortaid Intensive Therapy (with parabens and propylene glycol), Cortizone-10 (with aloe and parabens), Cortizone-10 External Anal Itch Relief Creme ( with aloe and parabens), Dermacort, (Solvay), DermiCort (Republic), Penecort (with benzyl alcohol and propylene glycol), Preparation H Hydrocortisone (with parabens and propylene glycol), (Wyeth), 2.5% Anusol-HC (with benzyl alcohol and propylene glycol), (Dermik). Gel: 1% CortaGel Extra Strength, (Norstar)., Rectal: Cream: 1 Proctocort ( with benzyl alcohol and propylene glycol), (Monarch), Suspension: 100 mg, 60 mL Cortenema ( with methylparaben), Hydrocortisone Enema, (Copley)., For more Formulations, Preparations (Complete) data for HYDROCORTISONE (14 total), please visit the HSDB record page., General Manufacturing Information: Pregn-4-ene-3, 20-dione, 11, 17, 21-trihydroxy-, (11.beta.)-: ACTIVE, RELATIVE ANTIINFLAMMATORY POTENCY= 1, RELATIVE SODIUM RETAINING POTENCY= 1., FROM TABLE.
Hydrocortisone is a carbon-based organic compound with CAS registry number 50-23-7 and molecular formula C21H30O5 (molecular weight 362.5), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 50-23-7
Its molecular formula C21H30O5 comprises 21 C, 30 H, 5 O atoms.
Also known as: Hydrocortisone · Hydrocortisone Base
Category: organic chemicals
The CAS registry number of Hydrocortisone is 50-23-7.
Molecular formula C21H30O5, molecular weight 362.5.
It is also registered under: Hydrocortisone, Hydrocortisone Base.
Recorded applications: Uses: Medicine (antiinflammatory agent), also used as the acetate and sodium succinate salts, THERAP CAT: Glucocorticoid, THERAP CAT (VET): Glucocorticoid, MEDICATION (VET), MEDICATION, Use (kg, approx.) in Germany (2009): >1000, Use (kg) in USA (2002): 21000, Use (kg) in France (2004): 453, Consumption (g per capita, approx.) in Germany (2009): 0.0122, Consumption (g per capita) in the USA (2002): 0.0744, Consumption (g per capita) in France (2004): 0.0075, Excretion rate: 0.06, Calculated removal (%): 45.9, Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients, Pharmaceuticals -> Hormones -> Steroid hormones, Pharmaceuticals -> Animal Drugs -> Approved in Taiwan, Household Products: Information on 6 consumer products that contain Hydrocortisone in the following categories is provided:, • Personal Care, • Pet Care, Methods of Manufacturing: ISOLATION FROM ADRENAL GLANDS, Preparation by microbioal transformation: H.C. Murrary, D.H. Perterson, US 2602769 (1952 to Upjohn), Formulations, Preparations: Ointment: 0.5% Cortizone-5, (Pfizer), 1% Cortizone-10, HydroSKIN, (Rugby), 2.5% Hytone, (Dermik). Pledgets (saturated with solution): 0.5% Massengill Medicated Soft Cloth Towelette (with parabens and propylene glycol), (GlaxoSmithKline). Solution: 1% Cortaid FastStick Maximum Strength (with alcohol and methylparaben), Cortaid Spray Maximum Strength (with alcohol and methylparaben), Cortizone-10 Scalp Itch Formula Liquid (with alcohol SD 40-2 60% v, v, benzyl alcohol, and propylene glycol), Penecort (with alcohol SD 40-2 57%, (Allergan), Texacort (with SD alcohol 33% and propylene glycol), (Sirius), 2.5% Texacort, (Sirius)., Lotion: 0.5% HydroSKIN, (Rugby). 1% Ala-Cort, (Del-Ray), Aquanil HC (with benzyl alcohol), (Person & Covey), Cetacort (with parabens), (Healthpoint), Dermacort (with benzyl alcohol), (Solvay) HydroSKIN, (Rugby) LactiCare-HC, (Stiefel) Nutracort (with parabens), Sarnol HC, (Stiefel), 2% Ala-Scalpt, 2.5% Hydrocortisone Lotion, (Glades), Hydrocortisone Lotion, (Major), Hytone (with propylene glycol), (Dermik), LactiCare-HC, Nutracort (with parabens), ProctoCream-HC (with benzyl alcohol), (Physicians Total Care)., Topical: Cream: 0.5% Cortizone-5 (with aloe and parabens), Cortizone for Kids ( with aloe and parabens), 1% Ala-Cort, Cortaid Intensive Therapy (with parabens and propylene glycol), Cortizone-10 (with aloe and parabens), Cortizone-10 External Anal Itch Relief Creme ( with aloe and parabens), Dermacort, (Solvay), DermiCort (Republic), Penecort (with benzyl alcohol and propylene glycol), Preparation H Hydrocortisone (with parabens and propylene glycol), (Wyeth), 2.5% Anusol-HC (with benzyl alcohol and propylene glycol), (Dermik). Gel: 1% CortaGel Extra Strength, (Norstar)., Rectal: Cream: 1 Proctocort ( with benzyl alcohol and propylene glycol), (Monarch), Suspension: 100 mg, 60 mL Cortenema ( with methylparaben), Hydrocortisone Enema, (Copley)., For more Formulations, Preparations (Complete) data for HYDROCORTISONE (14 total), please visit the HSDB record page., General Manufacturing Information: Pregn-4-ene-3, 20-dione, 11, 17, 21-trihydroxy-, (11.beta.)-: ACTIVE, RELATIVE ANTIINFLAMMATORY POTENCY= 1, RELATIVE SODIUM RETAINING POTENCY= 1., FROM TABLE.
Category: Organic Chemicals.
Public-database records for Hydrocortisone (CAS 50-23-7), reproduced here for independent cross-checking.
| GHS notification summary | 1.1% (3 / 274) |
|---|---|
| Reported hazard statements | H361 (86.5%), H373 (31.8%) |
This chemical does not meet GHS hazard criteria for 1.1% (3 of 274) of reports.
H361 (86.5%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
| GHS notification summary | 1.1% (3 / 274) |
|---|
| 熔点 | 220 |
|---|---|
| 熔点 | 220 °C |
| 溶解度 | 320 |
| 溶解度 | In water, 320 mg/L at 25 °C |
| 溶解度 | 0.32 mg/mL |
| LogP | 1.61 |
| LogP | log Kow = 1.61 |
| Collision Cross Section | 188.95 Ų [M+Cl]- |
| Collision Cross Section | 187.79 Ų [M+H]+ |
| Collision Cross Section | 191.98 Ų [M-H]- |
| CAS Registry Number | 50-23-7 |
|---|---|
| PubChem CID | 5754 |
| 分子式 | C21H30O5 |
| IUPAC 名称 | (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one |
| UNII（FDA） | WI4X0X7BPJ |
hydrocortisone; Cortisol; 50-23-7; Acticort; Cetacort; Hydrocortisyl; Cobadex; Hytone; Cortenema; Dermacort; Proctocort; Tarcortin; Cort-Dome; Efcorbin; Hycortol; Signef
| 分子量 | 362.5 |
|---|---|
| XLogP3 | 1.6 |
| 氢键供体数 | 3 |
| 氢键受体数 | 5 |
| 可旋转键数 | 2 |
| 精确质量 | 362.20932405 |
| 单同位素质量 | 362.20932405 |
| 拓扑极性表面积 | 94.8 |
| 重原子数 | 26 |
| 形式电荷 | 0 |
Hydrocortisone · CAS 50-23-7 · C21H30O5. UNII WI4X0X7BPJ. 熔点: 220; 熔点: 220 °C; 溶解度: 320.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd. · Reply within one business day.