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Hydrocortisone

CAS 50-23-7C21H30O5MW 362.5

Hydrocortisone（CAS 50-23-7）：分子式 C21H30O5、分子量 362.5；类别 有机化学品。

规格参数

CAS号50-23-7
分子式C21H30O5
分子量362.5
熔点220
LogP1.61
应用领域Uses: Medicine (antiinflammatory agent)、also used as the acetate and sodium succinate salts、THERAP CAT: Glucocorticoid、THERAP CAT (VET): Glucocorticoid、MEDICATION (VET)、MEDICATION、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in USA (2002): 21000、Use (kg) in France (2004): 453、Consumption (g per capita、approx.) in Germany (2009): 0.0122、Consumption (g per capita) in the USA (2002): 0.0744、Consumption (g per capita) in France (2004): 0.0075、Excretion rate: 0.06、Calculated removal (%): 45.9、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Pharmaceuticals -> Hormones -> Steroid hormones、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Household Products: Information on 6 consumer products that contain Hydrocortisone in the following categories is provided:、• Personal Care、• Pet Care、Methods of Manufacturing: ISOLATION FROM ADRENAL GLANDS、Preparation by microbioal transformation: H.C. Murrary、D.H. Perterson、US 2602769 (1952 to Upjohn)、Formulations、Preparations: Ointment: 0.5% Cortizone-5、(Pfizer)、1% Cortizone-10、HydroSKIN、(Rugby)、2.5% Hytone、(Dermik). Pledgets (saturated with solution): 0.5% Massengill Medicated Soft Cloth Towelette (with parabens and propylene glycol)、(GlaxoSmithKline). Solution: 1% Cortaid FastStick Maximum Strength (with alcohol and methylparaben)、Cortaid Spray Maximum Strength (with alcohol and methylparaben)、Cortizone-10 Scalp Itch Formula Liquid (with alcohol SD 40-2 60% v、v、benzyl alcohol、and propylene glycol)、Penecort (with alcohol SD 40-2 57%、(Allergan)、Texacort (with SD alcohol 33% and propylene glycol)、(Sirius)、2.5% Texacort、(Sirius).、Lotion: 0.5% HydroSKIN、(Rugby). 1% Ala-Cort、(Del-Ray)、Aquanil HC (with benzyl alcohol)、(Person & Covey)、Cetacort (with parabens)、(Healthpoint)、Dermacort (with benzyl alcohol)、(Solvay) HydroSKIN、(Rugby) LactiCare-HC、(Stiefel) Nutracort (with parabens)、Sarnol HC、(Stiefel)、2% Ala-Scalpt、2.5% Hydrocortisone Lotion、(Glades)、Hydrocortisone Lotion、(Major)、Hytone (with propylene glycol)、(Dermik)、LactiCare-HC、Nutracort (with parabens)、ProctoCream-HC (with benzyl alcohol)、(Physicians Total Care).、Topical: Cream: 0.5% Cortizone-5 (with aloe and parabens)、Cortizone for Kids ( with aloe and parabens)、1% Ala-Cort、Cortaid Intensive Therapy (with parabens and propylene glycol)、Cortizone-10 (with aloe and parabens)、Cortizone-10 External Anal Itch Relief Creme ( with aloe and parabens)、Dermacort、(Solvay)、DermiCort (Republic)、Penecort (with benzyl alcohol and propylene glycol)、Preparation H Hydrocortisone (with parabens and propylene glycol)、(Wyeth)、2.5% Anusol-HC (with benzyl alcohol and propylene glycol)、(Dermik). Gel: 1% CortaGel Extra Strength、(Norstar).、Rectal: Cream: 1 Proctocort ( with benzyl alcohol and propylene glycol)、(Monarch)、Suspension: 100 mg、60 mL Cortenema ( with methylparaben)、Hydrocortisone Enema、(Copley).、For more Formulations、Preparations (Complete) data for HYDROCORTISONE (14 total)、please visit the HSDB record page.、General Manufacturing Information: Pregn-4-ene-3、20-dione、11、17、21-trihydroxy-、(11.beta.)-: ACTIVE、RELATIVE ANTIINFLAMMATORY POTENCY= 1、RELATIVE SODIUM RETAINING POTENCY= 1.、FROM TABLE
类别Organic Chemicals

用途与场景

登记用途：Uses: Medicine (antiinflammatory agent)、also used as the acetate and sodium succinate salts、THERAP CAT: Glucocorticoid、THERAP CAT (VET): Glucocorticoid、MEDICATION (VET)、MEDICATION、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in USA (2002): 21000、Use (kg) in France (2004): 453、Consumption (g per capita、approx.) in Germany (2009): 0.0122、Consumption (g per capita) in the USA (2002): 0.0744、Consumption (g per capita) in France (2004): 0.0075、Excretion rate: 0.06、Calculated removal (%): 45.9、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Pharmaceuticals -> Hormones -> Steroid hormones、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Household Products: Information on 6 consumer products that contain Hydrocortisone in the following categories is provided:、• Personal Care、• Pet Care、Methods of Manufacturing: ISOLATION FROM ADRENAL GLANDS、Preparation by microbioal transformation: H.C. Murrary、D.H. Perterson、US 2602769 (1952 to Upjohn)、Formulations、Preparations: Ointment: 0.5% Cortizone-5、(Pfizer)、1% Cortizone-10、HydroSKIN、(Rugby)、2.5% Hytone、(Dermik). Pledgets (saturated with solution): 0.5% Massengill Medicated Soft Cloth Towelette (with parabens and propylene glycol)、(GlaxoSmithKline). Solution: 1% Cortaid FastStick Maximum Strength (with alcohol and methylparaben)、Cortaid Spray Maximum Strength (with alcohol and methylparaben)、Cortizone-10 Scalp Itch Formula Liquid (with alcohol SD 40-2 60% v、v、benzyl alcohol、and propylene glycol)、Penecort (with alcohol SD 40-2 57%、(Allergan)、Texacort (with SD alcohol 33% and propylene glycol)、(Sirius)、2.5% Texacort、(Sirius).、Lotion: 0.5% HydroSKIN、(Rugby). 1% Ala-Cort、(Del-Ray)、Aquanil HC (with benzyl alcohol)、(Person & Covey)、Cetacort (with parabens)、(Healthpoint)、Dermacort (with benzyl alcohol)、(Solvay) HydroSKIN、(Rugby) LactiCare-HC、(Stiefel) Nutracort (with parabens)、Sarnol HC、(Stiefel)、2% Ala-Scalpt、2.5% Hydrocortisone Lotion、(Glades)、Hydrocortisone Lotion、(Major)、Hytone (with propylene glycol)、(Dermik)、LactiCare-HC、Nutracort (with parabens)、ProctoCream-HC (with benzyl alcohol)、(Physicians Total Care).、Topical: Cream: 0.5% Cortizone-5 (with aloe and parabens)、Cortizone for Kids ( with aloe and parabens)、1% Ala-Cort、Cortaid Intensive Therapy (with parabens and propylene glycol)、Cortizone-10 (with aloe and parabens)、Cortizone-10 External Anal Itch Relief Creme ( with aloe and parabens)、Dermacort、(Solvay)、DermiCort (Republic)、Penecort (with benzyl alcohol and propylene glycol)、Preparation H Hydrocortisone (with parabens and propylene glycol)、(Wyeth)、2.5% Anusol-HC (with benzyl alcohol and propylene glycol)、(Dermik). Gel: 1% CortaGel Extra Strength、(Norstar).、Rectal: Cream: 1 Proctocort ( with benzyl alcohol and propylene glycol)、(Monarch)、Suspension: 100 mg、60 mL Cortenema ( with methylparaben)、Hydrocortisone Enema、(Copley).、For more Formulations、Preparations (Complete) data for HYDROCORTISONE (14 total)、please visit the HSDB record page.、General Manufacturing Information: Pregn-4-ene-3、20-dione、11、17、21-trihydroxy-、(11.beta.)-: ACTIVE、RELATIVE ANTIINFLAMMATORY POTENCY= 1、RELATIVE SODIUM RETAINING POTENCY= 1.、FROM TABLE。

采购档案

这个产品是什么

Hydrocortisone 是一种以碳骨架为基础的有机化合物，登记 CAS 号为 50-23-7，分子式 C21H30O5（分子量 362.5），归属于有机化学品大类化工原料。

识别信息

登记 CAS 号：50-23-7

其分子式 C21H30O5 由 21 个碳、30 个氢、5 个氧 组成。

别名/同义词：Hydrocortisone · Hydrocortisone Base

所属分类：有机化学品

常见问题

Hydrocortisone 的 CAS 号是多少？

Hydrocortisone 的 CAS 登记号为 50-23-7。

Hydrocortisone 的分子式与分子量是多少？

分子式 C21H30O5，分子量 362.5。

Hydrocortisone 还有哪些别名？

别名/同义词：Hydrocortisone、Hydrocortisone Base。

Hydrocortisone 的登记用途是什么？

登记用途：Uses: Medicine (antiinflammatory agent)、also used as the acetate and sodium succinate salts、THERAP CAT: Glucocorticoid、THERAP CAT (VET): Glucocorticoid、MEDICATION (VET)、MEDICATION、Use (kg、approx.) in Germany (2009): >1000、Use (kg) in USA (2002): 21000、Use (kg) in France (2004): 453、Consumption (g per capita、approx.) in Germany (2009): 0.0122、Consumption (g per capita) in the USA (2002): 0.0744、Consumption (g per capita) in France (2004): 0.0075、Excretion rate: 0.06、Calculated removal (%): 45.9、Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients、Pharmaceuticals -> Hormones -> Steroid hormones、Pharmaceuticals -> Animal Drugs -> Approved in Taiwan、Household Products: Information on 6 consumer products that contain Hydrocortisone in the following categories is provided:、• Personal Care、• Pet Care、Methods of Manufacturing: ISOLATION FROM ADRENAL GLANDS、Preparation by microbioal transformation: H.C. Murrary、D.H. Perterson、US 2602769 (1952 to Upjohn)、Formulations、Preparations: Ointment: 0.5% Cortizone-5、(Pfizer)、1% Cortizone-10、HydroSKIN、(Rugby)、2.5% Hytone、(Dermik). Pledgets (saturated with solution): 0.5% Massengill Medicated Soft Cloth Towelette (with parabens and propylene glycol)、(GlaxoSmithKline). Solution: 1% Cortaid FastStick Maximum Strength (with alcohol and methylparaben)、Cortaid Spray Maximum Strength (with alcohol and methylparaben)、Cortizone-10 Scalp Itch Formula Liquid (with alcohol SD 40-2 60% v、v、benzyl alcohol、and propylene glycol)、Penecort (with alcohol SD 40-2 57%、(Allergan)、Texacort (with SD alcohol 33% and propylene glycol)、(Sirius)、2.5% Texacort、(Sirius).、Lotion: 0.5% HydroSKIN、(Rugby). 1% Ala-Cort、(Del-Ray)、Aquanil HC (with benzyl alcohol)、(Person & Covey)、Cetacort (with parabens)、(Healthpoint)、Dermacort (with benzyl alcohol)、(Solvay) HydroSKIN、(Rugby) LactiCare-HC、(Stiefel) Nutracort (with parabens)、Sarnol HC、(Stiefel)、2% Ala-Scalpt、2.5% Hydrocortisone Lotion、(Glades)、Hydrocortisone Lotion、(Major)、Hytone (with propylene glycol)、(Dermik)、LactiCare-HC、Nutracort (with parabens)、ProctoCream-HC (with benzyl alcohol)、(Physicians Total Care).、Topical: Cream: 0.5% Cortizone-5 (with aloe and parabens)、Cortizone for Kids ( with aloe and parabens)、1% Ala-Cort、Cortaid Intensive Therapy (with parabens and propylene glycol)、Cortizone-10 (with aloe and parabens)、Cortizone-10 External Anal Itch Relief Creme ( with aloe and parabens)、Dermacort、(Solvay)、DermiCort (Republic)、Penecort (with benzyl alcohol and propylene glycol)、Preparation H Hydrocortisone (with parabens and propylene glycol)、(Wyeth)、2.5% Anusol-HC (with benzyl alcohol and propylene glycol)、(Dermik). Gel: 1% CortaGel Extra Strength、(Norstar).、Rectal: Cream: 1 Proctocort ( with benzyl alcohol and propylene glycol)、(Monarch)、Suspension: 100 mg、60 mL Cortenema ( with methylparaben)、Hydrocortisone Enema、(Copley).、For more Formulations、Preparations (Complete) data for HYDROCORTISONE (14 total)、please visit the HSDB record page.、General Manufacturing Information: Pregn-4-ene-3、20-dione、11、17、21-trihydroxy-、(11.beta.)-: ACTIVE、RELATIVE ANTIINFLAMMATORY POTENCY= 1、RELATIVE SODIUM RETAINING POTENCY= 1.、FROM TABLE。

Hydrocortisone 属于哪个分类？

所属分类：Organic Chemicals。

PubChem 公开数据

Hydrocortisone（CAS 50-23-7）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

GHS notification summary1.1% (3 / 274)
Reported hazard statementsH361 (86.5%), H373 (31.8%)

This chemical does not meet GHS hazard criteria for 1.1% (3 of 274) of reports.

H361 (86.5%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]

法规与备案状态

GHS notification summary1.1% (3 / 274)

物理形态与操作说明

  • Solid
  • Plates from alc or iso-propyl alc
  • Crystalline, striated blocks from absolute ethanol or isopropanol
  • White, crystalline powder
  • Odorless
  • Bitter taste

公开数据库收录的理化数据

熔点220
熔点220 °C
溶解度320
溶解度In water, 320 mg/L at 25 °C
溶解度0.32 mg/mL
LogP1.61
LogPlog Kow = 1.61
Collision Cross Section188.95 Ų [M+Cl]-
Collision Cross Section187.79 Ų [M+H]+
Collision Cross Section191.98 Ų [M-H]-

这个物质在各数据库里的编号

CAS Registry Number50-23-7
PubChem CID5754
分子式C21H30O5
IUPAC 名称(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
UNII（FDA）WI4X0X7BPJ

数据库记载的用途

  • Medicine (antiinflammatory agent), also used as the acetate and sodium succinate salts
  • THERAP CAT (VET): Glucocorticoid
  • Use (kg; approx.) in Germany (2009): >1000
  • Consumption (g per capita; approx.) in Germany (2009): 0.0122
  • Consumption (g per capita) in the USA (2002): 0.0744
  • Consumption (g per capita) in France (2004): 0.0075

它在各数据库里的别名

hydrocortisone; Cortisol; 50-23-7; Acticort; Cetacort; Hydrocortisyl; Cobadex; Hytone; Cortenema; Dermacort; Proctocort; Tarcortin; Cort-Dome; Efcorbin; Hycortol; Signef

计算机算出的分子描述符

分子量362.5
XLogP31.6
氢键供体数3
氢键受体数5
可旋转键数2
精确质量362.20932405
单同位素质量362.20932405
拓扑极性表面积94.8
重原子数26
形式电荷0

数据库摘要

Hydrocortisone · CAS 50-23-7 · C21H30O5. UNII WI4X0X7BPJ. 熔点: 220; 熔点: 220 °C; 溶解度: 320.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。

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