Insulin (CAS 9004-10-8) — formula C256H381N65O77S6, molecular weight 5794; category organic chemicals.
Documented applications: Uses: Hormone of carbohydrate and lipid metabolism that is used to treat diabetes, [Merck Index], MEDICATION, Indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus., Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients, Methods of Manufacturing: EXTRACTION OF THE PANCREAS OF SLAUGHTERED ANIMALS WITH ACIDIFIED DILUTE ALCOHOL, FOLLOWED BY PRECIPITATION WITH ABSOLUTE ALCOHOL, REDISSOLUTION, PRECIPITATION WITH ZINC CHLORIDE, & REDISSOLUTION IN WATER, SYNTHESIS OF HUMAN INSULIN: KATSOYAMIS ET AL, J AM CHEM SOC 88, 164, 166 (1966), RUTTENBERG, SCIENCE 177, 623 (1972) (FROM PORCINE INSULIN). ... APPROACHES TO COMMERCIAL SYNTHESIS: CHEM & ENG NEWS 52, 19 (APRIL 29, 1974)., BY USE OF PORCINE INSULIN AS STARTING MATERIAL, HUMAN INSULIN CAN NOW BE SYNTHESIZED WITH RELATIVE EASE., Formulations, Preparations: ISOPHANE INSULIN SUSPENSION, USP (NPH INSULIN, ISOPHANE INSULIN), GLOBIN ZINC INSULIN INJECTION, USP, PROTAMINE ZINC INSULIN SUSPENSION, INSULIN, INSULIN ZINC SUSPENSION PROMPT, INSULIN ZINC SUSPENSION (AMORPHOUS), SEMILENTE ILETIN & INSULIN ZINC SUSPENDED EXTENDED, INSULIN ZINC SUSPENSION (CRYSTALLINE), ULTRALENTE ILETIN, INSULIN ZINC SUSPENSION, Consumption Patterns: ESSENTIALLY 100% AS A MEDICINAL (1976), U.S. Production: (1972) PROBABLY GREATER THAN 4.54X10+5 G, (1975) PROBABLY GREATER THAN 4.54X10+5 G, U.S. Imports: (1972) No Data, (1975) No Data, U.S. Exports: (1972) No Data, General Manufacturing Information: SINCE MOST SYNTHETIC METHODS GIVE LOW YIELDS, MAJOR SOURCE OF HORMONE FOR HUMAN CONSUMPTION REMAINS PANCREAS OF SLAUGHTERED ANIMALS., INSULIN CAN EXIST AS MONOMER, DIMER, OR HEXAMER COMPOSED OF THREE SUCH DIMERS., ON CONVERSION OF HUMAN PROINSULIN TO INSULIN, 4 BASIC AMINO ACIDS (ARGININE 31, 32, LYSINE 64 & ARGININE 65) & CONNECTOR OR C-PEPTIDE MADE UP OF RESIDUES 31-65 ARE REMOVED. RESULTANT INSULIN MOLECULE...A CHAIN WITH GLYCINE AS AMINO-TERMINAL RESIDUE & B CHAIN WITH PHENYLALANINE @ AMINO TERMINUS., WITH MOL WT OF ABOUT 6000, IS MADE UP OF TWO CHAINS OF AMINO ACIDS JOINED TOGETHER BY DISULFIDE LINKAGES. ...THE TWO CHAINS, ARE, TERMED A FOR ACIDIC & B FOR BASIC..., For more General Manufacturing Information (Complete) data for INSULIN INJECTION (7 total), please visit the HSDB record page..
Insulin is a carbon-based organic compound with CAS registry number 9004-10-8 and molecular formula C256H381N65O77S6 (molecular weight 5794), belonging to the organic chemicals segment of chemical raw materials.
CAS number: 9004-10-8
Its molecular formula C256H381N65O77S6 comprises 256 C, 381 H, 65 N, 77 O, 6 S atoms.
Also known as: Insulin · Bovine Insulin
Category: organic chemicals
The CAS registry number of Insulin is 9004-10-8.
Molecular formula C256H381N65O77S6, molecular weight 5794.
It is also registered under: Insulin, Bovine Insulin.
Recorded applications: Uses: Hormone of carbohydrate and lipid metabolism that is used to treat diabetes, [Merck Index], MEDICATION, Indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus., Use Classification: Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients, Methods of Manufacturing: EXTRACTION OF THE PANCREAS OF SLAUGHTERED ANIMALS WITH ACIDIFIED DILUTE ALCOHOL, FOLLOWED BY PRECIPITATION WITH ABSOLUTE ALCOHOL, REDISSOLUTION, PRECIPITATION WITH ZINC CHLORIDE, & REDISSOLUTION IN WATER, SYNTHESIS OF HUMAN INSULIN: KATSOYAMIS ET AL, J AM CHEM SOC 88, 164, 166 (1966), RUTTENBERG, SCIENCE 177, 623 (1972) (FROM PORCINE INSULIN). ... APPROACHES TO COMMERCIAL SYNTHESIS: CHEM & ENG NEWS 52, 19 (APRIL 29, 1974)., BY USE OF PORCINE INSULIN AS STARTING MATERIAL, HUMAN INSULIN CAN NOW BE SYNTHESIZED WITH RELATIVE EASE., Formulations, Preparations: ISOPHANE INSULIN SUSPENSION, USP (NPH INSULIN, ISOPHANE INSULIN), GLOBIN ZINC INSULIN INJECTION, USP, PROTAMINE ZINC INSULIN SUSPENSION, INSULIN, INSULIN ZINC SUSPENSION PROMPT, INSULIN ZINC SUSPENSION (AMORPHOUS), SEMILENTE ILETIN & INSULIN ZINC SUSPENDED EXTENDED, INSULIN ZINC SUSPENSION (CRYSTALLINE), ULTRALENTE ILETIN, INSULIN ZINC SUSPENSION, Consumption Patterns: ESSENTIALLY 100% AS A MEDICINAL (1976), U.S. Production: (1972) PROBABLY GREATER THAN 4.54X10+5 G, (1975) PROBABLY GREATER THAN 4.54X10+5 G, U.S. Imports: (1972) No Data, (1975) No Data, U.S. Exports: (1972) No Data, General Manufacturing Information: SINCE MOST SYNTHETIC METHODS GIVE LOW YIELDS, MAJOR SOURCE OF HORMONE FOR HUMAN CONSUMPTION REMAINS PANCREAS OF SLAUGHTERED ANIMALS., INSULIN CAN EXIST AS MONOMER, DIMER, OR HEXAMER COMPOSED OF THREE SUCH DIMERS., ON CONVERSION OF HUMAN PROINSULIN TO INSULIN, 4 BASIC AMINO ACIDS (ARGININE 31, 32, LYSINE 64 & ARGININE 65) & CONNECTOR OR C-PEPTIDE MADE UP OF RESIDUES 31-65 ARE REMOVED. RESULTANT INSULIN MOLECULE...A CHAIN WITH GLYCINE AS AMINO-TERMINAL RESIDUE & B CHAIN WITH PHENYLALANINE @ AMINO TERMINUS., WITH MOL WT OF ABOUT 6000, IS MADE UP OF TWO CHAINS OF AMINO ACIDS JOINED TOGETHER BY DISULFIDE LINKAGES. ...THE TWO CHAINS, ARE, TERMED A FOR ACIDIC & B FOR BASIC..., For more General Manufacturing Information (Complete) data for INSULIN INJECTION (7 total), please visit the HSDB record page..
Category: Organic Chemicals.
Public-database records for Insulin (CAS 9004-10-8), reproduced here for independent cross-checking.
| GHS notification summary | 99.1% (116 / 117) |
|---|
This chemical does not meet GHS hazard criteria for 99.1% (116 of 117) of all reports.
Reported as not meeting GHS hazard criteria by 116 of 117 companies (only 0.9% companies provided GHS information). For more detailed information, please visit ECHA C&L website.
| GHS notification summary | 99.1% (116 / 117) |
|---|
| pH | 2.5-3.5 |
|---|
| CAS Registry Number | 9004-10-8 |
|---|---|
| PubChem CID | 70678557 |
| 分子式 | C256H381N65O77S6 |
9004-10-8; Endopancrine; Decurvon; Dermulin; Insular; Insulyl; Iszilin; Musulin; Iletin; Intesulin B; Insulina dalanatada; Insulinum dalanatum; AERx; INSULIN INJECTION; Insulina iniettabile neutra; Insulini injectio neutralis
| 分子量 | 5794 |
|---|---|
| XLogP3 | -12.8 |
| 氢键供体数 | 78 |
| 氢键受体数 | 89 |
| 可旋转键数 | 178 |
| 精确质量 | 5791.6287098 |
| 单同位素质量 | 5789.6220002 |
| 拓扑极性表面积 | 2450 |
| 重原子数 | 404 |
| 形式电荷 | 0 |
Insulin · CAS 9004-10-8 · C256H381N65O77S6. pH: 2.5-3.5.
Source: PubChem / Wikidata; the batch COA governs where values differ.
Supplier: Jinan Shenghe Chemical Co., Ltd. · Reply within one business day.