alphacalcidol

Description

alphacalcidol · CAS 41294-56-8 · C27H44O2. UNII URQ2517572. Melting Point: 136; Melting Point: 136 °C; Solubility: <1 mg/mL.

Identification

CAS Registry Number	41294-56-8
PubChem CID	5282181
Molecular formula	C27H44O2
IUPAC name	trans-(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
UNII (FDA)	URQ2517572

Computed Descriptors

Molecular Weight	400.6
XLogP3	6.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	6
Exact Mass	400.334130642
Monoisotopic Mass	400.334130642
Topological Polar Surface Area	40.5
Heavy Atom Count	29
Formal Charge	0

Physical & Chemical Properties

Melting Point	136
Melting Point	136 °C
Solubility	<1 mg/mL
Solubility	1.63e-03 g/L

Physical description & handling notes

• Solid

GHS Hazard Classification

Reported hazard statements	H300 (100%), H310 (89.6%), H330 (91.7%)

Documented Uses

• Alfacalcidol is indicated in adult patients with chronic renal failure for the management of hypocalcemia, secondary hyperparathyroidism, or osteodystrophy. Alfacalcidol is indicated in the management of nutritional and malabsorptive rickets and osteomalacia, vitamin D-dependent rickets and osteomalacia, and hypophosphataemic vitamin D resistant rickets and osteomalacia.
• Take with or without food. Food does not affect the bioavailability.
• Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
• A - Alimentary tract and metabolism
• A11C - Vitamin a and d, incl. combinations of the two
• A11CC - Vitamin d and analogues

Synonyms

alfacalcidol; 41294-56-8; 1-Hydroxycholecalciferol; Alphacalcidol; 1alpha-Hydroxyvitamin D3; Alfarol; EinsAlpha; 1-Hydroxyvitamin D3; 1alpha-Hydroxycholecalciferol; Alsiodol; Oxydevit; Bondiol; alpha-Calcidol; One-Alpha; Etalpha; Alfacalcidolum

Frequently Asked Questions

What are the CAS number and molecular formula of alphacalcidol?

CAS 41294-56-8; molecular formula C27H44O2; molecular weight — g/mol.

What other names is alphacalcidol known by?

alfacalcidol, 41294-56-8, 1-Hydroxycholecalciferol, Alphacalcidol, 1alpha-Hydroxyvitamin D3, Alfarol.

Is alphacalcidol classified as hazardous?

Hazard statements reported: H300, H310, H330.

What are the key physical properties of alphacalcidol?

Melting Point: 136; Melting Point: 136 °C; Solubility: <1 mg/mL; Solubility: 1.63e-03 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.