溴苯那敏

Description

brompheniramine · CAS 86-22-6 · C16H19BrN2. UNII H57G17P2FN. Boiling Point: 149.5; Boiling Point: 150 °C at 0.5 mm Hg; Melting Point: < 25 °C.

Identification

CAS Registry Number	86-22-6
PubChem CID	6834
Molecular formula	C16H19BrN2
IUPAC name	3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
UNII (FDA)	H57G17P2FN

Computed Descriptors

Molecular Weight	319.24
XLogP3	3.5
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	318.07316
Monoisotopic Mass	318.07316
Topological Polar Surface Area	16.1
Heavy Atom Count	19
Formal Charge	0

Physical & Chemical Properties

Boiling Point	149.5
Boiling Point	150 °C at 0.5 mm Hg
Melting Point	< 25 °C
LogP	3.4
Dissociation Constants	10.1

Physical description & handling notes

• Solid
• Oily liquid with slightly yellow color
• Characteristic amine-like
• pH of 2% aq soln about 5; mp: 132-134 °C; crystals /Maleate/
• Freely soluble (maleate salt)
• ODORLESS; WHITE, CRYSTALLINE POWDER; 1 G SOL IN ABOUT 15 ML CHLOROFORM, ABOUT 5 ML WATER, ABOUT 15 ML ALC /MALEATE/

Regulatory Status

GHS notification summary	2.5% (1 / 40)

GHS Hazard Classification

GHS notification summary	2.5% (1 / 40)
Reported hazard statements	H302 (97.5%)

Documented Uses

• For the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing.
• REACTION OF ALPHA-(P-BROMOPHENYL)-2-PYRIDINE-ACETONITRILE WITH SODAMIDE FOLLOWED BY CONDENSATION WITH 2-CHLORO-N,N-DIMETHYLETHYLAMINE, CONVERSION TO THE CORRESPONDING ACID, AND DECARBOXYLATION BY TREATMENT WITH SULFURIC ACID
• ALPHA-(P-BROMOPHENYL)-2-PYRIDINE-ACETONITRILE IS CONVERTED TO ITS SODIUM DERIV.../WHICH/ IS...CONDENSED WITH 2-CHLORO-N,N-DIMETHYLETHYLAMINE. RESULTING NITRILE...CONVERTED TO ITS CORRESPONDING ACID.../&/ DECARBOXYLATED... MIXT /MADE/ ALKALINE, BROMPHENIRAMINE BASE...EXTRACTED & REACTED WITH...MALEIC ACID. /MALEATE/
• Preparation from alpha-(p-bromophenyl)-alpha-(beta-dimethylaminoethyl)-2-pyridylacetonitrile: Sperber et al., US 2567245 (1951); US 2676964 (1954 to Schering).
• ESSENTIALLY 100% AS AN ANTIHISTAMINE (AS MALEATE)
• (1977) PROBABLY MORE THAN 9.08X10+5 G-MALEATE

Synonyms

BROMPHENIRAMINE; 86-22-6; Parabromdylamine; Bromfeniramina; Brompheniraminum; Bromfed; 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine; Bromfenex; Brotane; 1-(p-Bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane; 3-(p-Bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine; 2-(p-Bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine; Dimetapp Allergy; 3-(4-Bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine; H57G17P2FN; gamma-(4-Bromophenyl)-N,N-dimethyl-2-pyridinepropanamine

Frequently Asked Questions

What are the CAS number and molecular formula of brompheniramine?

CAS 86-22-6; molecular formula C16H19BrN2; molecular weight — g/mol.

What other names is brompheniramine known by?

BROMPHENIRAMINE, 86-22-6, Parabromdylamine, Bromfeniramina, Brompheniraminum, Bromfed.

Is brompheniramine classified as hazardous?

2.5% of GHS notifications report no hazard classification (1 of 40).

What are the key physical properties of brompheniramine?

Boiling Point: 149.5; Boiling Point: 150 °C at 0.5 mm Hg; Melting Point: < 25 °C; LogP: 3.4.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.