克拉维酸

Description

Clavulanic Acid · CAS 58001-44-8 · C8H9NO5. UNII 23521W1S24. Boiling Point: 545.8; Melting Point: 117.5-118; Melting Point: 117.5 - 118 °C.

Identification

CAS Registry Number	58001-44-8
PubChem CID	5280980
Molecular formula	C8H9NO5
IUPAC name	(2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
UNII (FDA)	23521W1S24

Computed Descriptors

Molecular Weight	199.16
XLogP3	-1.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	199.04807239
Monoisotopic Mass	199.04807239
Topological Polar Surface Area	87.1
Heavy Atom Count	14
Formal Charge	0

Physical & Chemical Properties

Boiling Point	545.8
Melting Point	117.5-118
Melting Point	117.5 - 118 °C
Solubility	3.37e+02 g/L
LogP	-2.3
LogP	-1.5
Dissociation Constants	2.7

Physical description & handling notes

• Solid
• Clavulanic acid inactivates some beta-lactamase enzymes that are produced by bacteria, therefore preventing enzymatic destruction of amoxicillin. This helps to treat a variety of bacterial infections which would otherwise be resistant to antibiotics without the addition of clavulanic acid.

Documented Uses

• Use (kg) in Switzerland (2009): >2500
• Use (kg; approx.) in Germany (2009): >2500
• Use (kg) in France (2004): 22699
• Consumption (g per capita) in Switzerland (2009): 0.32
• Consumption (g per capita; approx.) in Germany (2009): 0.031
• Consumption (g per capita) in the USA (2002): 0.36

Synonyms

CLAVULANIC ACID; 58001-44-8; Acido clavulanico; Acide clavulanique; Antibiotic MM 14151; acidum clavulanicum; Clavulansaeure; (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; MM 14151; BRL-14151; Serdaxin; BRL 14151; rx-10100; (Z)-(2R,5R)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid; CHEBI:48947; 23521W1S24

Frequently Asked Questions

What are the CAS number and molecular formula of Clavulanic Acid?

CAS 58001-44-8; molecular formula C8H9NO5; molecular weight — g/mol.

What other names is Clavulanic Acid known by?

CLAVULANIC ACID, 58001-44-8, Acido clavulanico, Acide clavulanique, Antibiotic MM 14151, acidum clavulanicum.

What are the key physical properties of Clavulanic Acid?

Boiling Point: 545.8; Melting Point: 117.5-118; Melting Point: 117.5 - 118 °C; Solubility: 3.37e+02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.