氯膦酸

Description

Clodronic acid · CAS 10596-23-3 · CH4Cl2O6P2. UNII 0813BZ6866. Melting Point: 250; Melting Point: 250 °C; Solubility: 7.47e+00 g/L.

Identification

CAS Registry Number	10596-23-3
PubChem CID	25419
Molecular formula	CH4Cl2O6P2
IUPAC name	[dichloro(phosphono)methyl]phosphonic acid
UNII (FDA)	0813BZ6866

Computed Descriptors

Molecular Weight	244.89
XLogP3	-2.1
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	243.8860172
Monoisotopic Mass	243.8860172
Topological Polar Surface Area	115
Heavy Atom Count	11
Formal Charge	0

Physical & Chemical Properties

Melting Point	250
Melting Point	250 °C
Solubility	7.47e+00 g/L
LogP	-2.4

Physical description & handling notes

• Solid

Documented Uses

• Use (kg; approx.) in Germany (2009): >500
• Consumption (g per capita; approx.) in Germany (2009): 0.00611
• A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification. For the management of hypercalcemia of malignancy and as an adjunct in the management of osteolysis resulting from bone metastases of malignant tumors.
• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Clodronic acid is indicated as an adjunct in the management of osteolysis from bone metastases of malignant tumors and for management of hypercalcemia of malignancy.
• Take on an empty stomach. Co-administration with food may decrease absorption.

Synonyms

Clodronic Acid; 10596-23-3; Clodronate; (Dichloromethylene)diphosphonic acid; Acido clodronico; Acide clodronique; [dichloro(phosphono)methyl]phosphonic acid; Acidum clodronicum; Clodronsaeure; Dichloromethylidene diphosphonate; (Dichloromethylene)bisphosphonic acid; Dichloromethanediphosphonic acid; Phosphonic acid, (dichloromethylene)bis-; Clasteon; Loron; (Dichloro-phosphono-methyl)-phosphonic acid

Frequently Asked Questions

What are the CAS number and molecular formula of Clodronic acid?

CAS 10596-23-3; molecular formula CH4Cl2O6P2; molecular weight — g/mol.

What other names is Clodronic acid known by?

Clodronic Acid, 10596-23-3, Clodronate, (Dichloromethylene)diphosphonic acid, Acido clodronico, Acide clodronique.

What are the key physical properties of Clodronic acid?

Melting Point: 250; Melting Point: 250 °C; Solubility: 7.47e+00 g/L; LogP: -2.4.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.