环巴明

环巴明（CAS 4449-51-8）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• 218.7 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID6043709]
• 219.1 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID6043709]

这个物质在各数据库里的编号

数据库记载的用途

• It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.
• 11-Deoxojervine is a precursor for the biosynthesis of jervine in Veratrum grandiflorum.
• Plants have and continue to provide medicine with an abundance of pharmacologically interesting and useful chemicals. In recent years, cyclopamine, a steroidal alkaloid isolated from Veratrum californicum, has been instrumental in dissecting the sonic hedgehog pathway. This brief report outlines cyclopamine's discovery with discussion of its potential application to clinical dermatology.
• 3 OR 4. 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OZ & 1 PINT (OR 1 LB) FOR 70 KG PERSON (150 LB). 4= VERY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 50-500 MG/KG, BETWEEN 1 TEASPOON & 1 OZ FOR 70 KG PERSON (150 LB). /VERATRUM VIRIDE ALKALOIDS/
• Conversion to teratogen of cyclopamine by rumen microorganisms is not essential. Indeed, ruminant sheep and non-ruminant rabbits were about equally susceptible to cyclopamine on a body weight basis.

它在各数据库里的别名

CYCLOPAMINE; 4449-51-8; 11-Deoxojervine; 11-Deoxyjervine; DTXSID6043709; Alkaloid V; ZH658AJ192; NSC-734950; DTXCID4023709; Veratraman-3-ol, 17,23-epoxy-, (3beta,23beta)-; (3beta23R)-17,23-Epoxyveratraman-3-ol; 3,4'-Dinitroflavone; RefChem:129819; 628-058-8; MFCD09878269; Jervine, 11-deoxo-

计算机算出的分子描述符

数据库摘要

Cyclopamine · CAS 4449-51-8 · C27H41NO2. UNII ZH658AJ192.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。