皮质瑞林羊三氟甲酸盐

皮质瑞林羊三氟甲酸盐（CAS 121249-14-7）的公开数据库记录，列此仅供独立核对。

物理形态与操作说明

• In normal subjects, intravenous administration of corticorelin results in a rapid and sustained increase of plasma ACTH levels and a near parallel increase of plasma cortisol. In addition, intravenous administration of corticorelin to normal subjects causes a concomitant and prolonged release of the related proopiomelanocortin peptides β- and γ-lipotropins (β -and γ-LPH) and β-endorphin (β -END).

这个物质在各数据库里的编号

数据库记载的用途

• Corticorelin is indicated for use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.
• Plasma ACTH levels in normal subjects increased 2 minutes after injection of corticorelin doses of ≥0.3 mcg/kg and reached peak levels after 10-15 minutes. Plasma cortisol levels increased within 10 minutes and reached peak levels at 30 to 60 minutes.
• The mean volume of distribution for IR-corticorelin is 6.2 ± 0.5 L
• Corticorelin does not appear to be bound specifically by a circulating plasma protein.
• Plasma half-lives for IR-corticorelin are 11.6 ± 1.5 minutes (mean ± SE) for the fast component and 73 ± 8 minutes for the slow component.
• Corticorelin is a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. It is used as a diagnostic agent to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion.

它在各数据库里的别名

Corticorelin ovine triflutate; Corticorelin triflutate; 56X54T817Q; RefChem:58077; 121249-14-7; Acthrel; Corticorelin ovine; Ovine CRH; 79804-71-0; Ovine ACTH releasing factor; Ovine CRF 41; Ovine corticotropin-releasing factor; Corticotropin-releasing factor (sheep); Sheep corticotropin-releasing factor (1-41); Corticotropin-releasing factor (sheep hypothalamus); Ovine CRF

计算机算出的分子描述符

数据库摘要

Corticorelin Ovine Triflutate · CAS 121249-14-7 · C205H339N59O63S. UNII 56X54T817Q.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。