糠酸二氯沙尼特

糠酸二氯沙尼特（CAS 3736-81-0）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• Solid
• >49.2 [ug/mL] (The mean of the results at pH 7.4)
• 171.7 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• Diloxanide is a luminal amebicide, however the mechanism of action of diloxanide is unknown. Diloxanide destroys the trophozoites of E. histolytica that eventually form into cysts. The cysts are then excreted by persons infected with asymptomatic amebiasis. Diloxanide furoate is a prodrug, and is hydrolyzed in the gastrointestinal tract to produce diloxanide, the active ingredient.

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• Diloxanide is used alone as a primary agent in the treatment of asymptomatic (cyst passers) intestinal amebiasis caused by Entamoeba histolytica. Diloxanide may also be used concurrently, or sequentially, with other agents such as the nitroimidazoles (eg. metronidazole) in the treatment of invasive or extraintestinal forms of amebiasis.
• Agents which are destructive to amebae, especially the parasitic species causing AMEBIASIS in man and animal.
• Bioavailability is 90% (in diloxanide parental form), however diloxanide furoate is slowly absorbed from the gastrointestinal tract.
• Renal (90%, rapidly excreted as glucuronide metabolite). 10% is excreted in the feces as diloxanide.
• Hydrolyzed to furoic acid and diloxanide, which undergoes extensive glucuronidation (99% of diloxanide occurs as glucuronide and 1% as free diloxanide in the systemic circulation).
• Unknown. Diloxanide may inhibit protein synthesis.

它在各数据库里的别名

DILOXANIDE FUROATE; 3736-81-0; Dichlofurazol; Furentomin; Amebiazol; Histomibal; Entamide furoate; Diloxanid furoate; Diclofurazol; Miforon; 8073 CB; DTXSID8048999; Diloxanidi furoas; NSC-759146; YP4N72IW34; Diloxanide furoate (USP)

计算机算出的分子描述符

数据库摘要

diloxanide furoate · CAS 3736-81-0 · C14H11Cl2NO4. UNII YP4N72IW34. LogP: 2.24.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。