富马酸二甲酯

Description

Dimethyl fumarate · CAS 624-49-7 · C6H8O4. UNII FO2303MNI2. Boiling Point: 192; Boiling Point: 193 °C; Melting Point: 102.

Identification

CAS Registry Number	624-49-7
PubChem CID	637568
Molecular formula	C6H8O4
IUPAC name	dimethyl (E)-but-2-enedioate
UNII (FDA)	FO2303MNI2

Computed Descriptors

Molecular Weight	144.12
XLogP3	0.7
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	144.04225873
Monoisotopic Mass	144.04225873
Topological Polar Surface Area	52.6
Heavy Atom Count	10
Formal Charge	0

Physical & Chemical Properties

Boiling Point	192
Boiling Point	193 °C
Melting Point	102
Melting Point	101.70 °C
Melting Point	102 °C
Melting Point	104 °C
Density	1.37 g/cu cm at 20 °C
Density	1.37 g/cm³
Vapor Pressure	3.83 [mmHg]
LogP	log Kow = 0.74

Physical description & handling notes

• Solid; [HSDB] Off-white crystalline solid; [Sigma-Aldrich MSDS]
• Solid
• WHITE CRYSTALLINE POWDER.
• White to off-white powder
• Crystals
• Highly soluble in water

GHS Hazard Classification

Reported hazard statements	H312 (100%), H315 (44.5%), H317 (41.5%), H319 (42.1%), H335 (15.9%), H411 (12.2%), H302, H401

Documented Uses

• Used to treat psoriasis and multiple sclerosis; [REPROTOX] Used to make products with formyl derivatives; [HSDB] Used as a product preservative; [ECHA - Annex XV Restriction Report] Used in Asia as a wide-spectrum biocide; [Kanerva, p. 1786]
• Use restricted to concentrations of 0.1 mg/kg; [ECHA - RAC]
• Using Disinfectants or Biocides [Category: Clean]
• Dermatologic Agents; Immunosuppressive Agents; Radiation-Sensitizing Agents
• Used with catalyst to produce products containing formyl derivatives.
• Dimethylfumarate (DMF) is used by producers as a biocide to kill molds that may cause products such as furniture or shoes to deteriorate during storage or transportation in a humid climate. Placed in "Desiccant" sachets inside the furniture or footwear boxes, DMF evaporates and impregnates the product, protecting it from molds.

Synonyms

Dimethyl fumarate; 624-49-7; Tecfidera; Fumaric acid dimethyl ester; Dimethylfumarate; Fumaderm; Fumaric acid, dimethyl ester; BG-12; Boletic acid dimethyl ester; BG 12 compound; Panaclar; Dimethyl trans-ethylenedicarboxylate; BG-00012; dimethyl (2E)-but-2-enedioate; trans-Butenedioic acid dimethyl ester; Allomaleic acid dimethyl ester

Frequently Asked Questions

What are the CAS number and molecular formula of Dimethyl fumarate?

CAS 624-49-7; molecular formula C6H8O4; molecular weight — g/mol.

What other names is Dimethyl fumarate known by?

Dimethyl fumarate, 624-49-7, Tecfidera, Fumaric acid dimethyl ester, Dimethylfumarate, Fumaderm.

Is Dimethyl fumarate classified as hazardous?

Hazard statements reported: H312, H315, H317, H319, H335.

What are the key physical properties of Dimethyl fumarate?

Boiling Point: 192; Boiling Point: 193 °C; Melting Point: 102; Melting Point: 101.70 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.