乙基琥珀酸红霉素

Description

ErythromycinEthylsuccinate · CAS 1264-62-6 · C43H75NO16. UNII 1014KSJ86F. Dissociation Constants: PKA 7.1.

Identification

CAS Registry Number	1264-62-6
PubChem CID	443953
Molecular formula	C43H75NO16
IUPAC name	4-O-[(2S,3R,4S,6R)-4-(dimethylamino)-2-[[(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yl]oxy]-6-methyloxan-3-yl] 1-O-ethyl butanedioate
UNII (FDA)	1014KSJ86F

Computed Descriptors

Molecular Weight	862.1
XLogP3	3.4
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	17
Rotatable Bond Count	14
Exact Mass	861.50858530
Monoisotopic Mass	861.50858530
Topological Polar Surface Area	226
Heavy Atom Count	60
Formal Charge	0

Physical & Chemical Properties

Dissociation Constants	PKA 7.1

Physical description & handling notes

• WHITE OR SLIGHTLY YELLOW, CRYSTALLINE POWDER
• ODORLESS OR PRACTICALLY SO
• PRACTICALLY TASTELESS
• FREELY SOL IN ACETONE & CHLOROFORM; SOL IN 95% ETHANOL & BENZENE; SPARINGLY SOL IN ETHER; VERY SLIGHTLY SOL IN WATER
• FREELY SOLUBLE IN ALC, SOL IN POLYETHYLENE GLYCOL
• AFTER RECONSTITUTION OF COMMERCIALLY AVAILABLE POWDER, SUSPENSIONS ARE STABLE FOR 10 DAYS @ 2-8 °C

GHS Hazard Classification

Reported hazard statements	H317 (29.9%), H319 (71.5%), H334 (29.9%)

Documented Uses

• ERYTHROMYCIN IS ESTERIFIED AT THE 2' POSITION BY REACTING IT WITH ETHYL 3-CHLOROFORMYLPROPIONATE [CLCOCH2CH2CO2ET] IN DRY ACETONE IN THE PRESENCE OF SODIUM BICARBONATE.
• ERYTHROMYCIN ETHYLSUCCINATE INJECTION, USP (ERYTHROCIN ETHYLSUCCINATE-IM), CONTAINS 50 MG/ML IN 2- & 10-ML CONTAINERS FOR IM INJECTION. THIS PREPN INCL BUTYL AMINOBENZOATE (2%) AS LOCAL ANESTHETIC.
• ...USED IN FLAVORED ORAL "SUSPENSIONS" FOR PEDIATRIC USE.
• ...CONTAINS THE EQUIVALENT OF NOT LESS THAN 76.5% OF ERYTHROMYCIN BASE.
• WHILE CROSS-RESISTANCE BETWEEN ERYTHROMYCIN & OTHER ANTIMICROBIAL AGENTS DOES NOT USUALLY OCCUR, IT HAS BEEN NOTED BETWEEN LINCOMYCIN & ERYTHROMYCIN IN STRAINS OF VIRIDANS GROUP OF STREPTOCOCCI ISOLATED FROM PT TREATED WITH EITHER AGENT. /ERYTHROMYCIN/
• INCIDENCE OF ERYTHROMYCIN-RESISTANT STRAINS OF STAPH AUREUS HAS BEEN INCR; IN SOME HOSPITALS 50% OF STRAINS ARE NOT INHIBITED BY DRUG. OCCASIONAL STRAINS OF STREPTOCOCCUS PYOGENES & STREP (D) PNEUMONIAE RESISTANT TO DRUG HAVE BEEN RECOVERED FROM PT. /ERYTHROMYCIN/

Synonyms

erythromycin ethylsuccinate; 1264-62-6; Erythromycin ethyl succinate; Erythrocin ethyl succinate; anamycin; arpimycin; Wyamycin; ERY-PED; PEDIAMYCIN 400; Erythromycin, ethyl succinate; Erythromycin 2'-(ethyl butanedioate); Esinol; DTXSID4022993; 1014KSJ86F; Erythromycin, mono(ethyl succinate); Erythromycin, mono(ethyl succinate) (ester)

Frequently Asked Questions

What are the CAS number and molecular formula of ErythromycinEthylsuccinate?

CAS 1264-62-6; molecular formula C43H75NO16; molecular weight — g/mol.

What other names is ErythromycinEthylsuccinate known by?

erythromycin ethylsuccinate, 1264-62-6, Erythromycin ethyl succinate, Erythrocin ethyl succinate, anamycin, arpimycin.

Is ErythromycinEthylsuccinate classified as hazardous?

Hazard statements reported: H317, H319, H334.

What are the key physical properties of ErythromycinEthylsuccinate?

Dissociation Constants: PKA 7.1.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.