fluoxetine hydrochloride

Description

fluoxetine hydrochloride · CAS 59333-67-4 · C17H19ClF3NO. UNII I9W7N6B1KJ. Melting Point: 158.4-158.9 °C.

Identification

CAS Registry Number	59333-67-4
PubChem CID	62857
Molecular formula	C17H19ClF3NO
IUPAC name	N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine;hydrochloride
UNII (FDA)	I9W7N6B1KJ

Computed Descriptors

Molecular Weight	345.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	6
Exact Mass	345.1107264
Monoisotopic Mass	345.1107264
Topological Polar Surface Area	21.3
Heavy Atom Count	23
Formal Charge	0
Complexity	308

Physical & Chemical Properties

Melting Point	158.4-158.9 °C

Physical description & handling notes

• White to off-white crystalline solid
• Crystals from ethyl acetate-methanol, mp: 179-182 °C /Oxalate/
• Sol (mg/mL): methanol, ethanol >100; acetone, acetonitrile, chloroform 33-100; dichloromethane 5-10; ethyl acetate 2-2.5; toluene, cyclohexane, hexane 0.5-0.67
• Maximum sol in water: 14 mg/mL

Regulatory Status

GHS notification summary	0.8% (1 / 131)

GHS Hazard Classification

GHS notification summary	0.8% (1 / 131)
Reported hazard statements	H302 (97.7%), H312 (13.7%), H318 (81.7%), H332 (14.5%), H361 (16.8%), H400 (93.1%)

Documented Uses

• MEDICATION: Antidepressant; antiobessional; antibulimic
• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Commercially available as the hydrochloride salt.
• (S)-Fluoxetine was synthesized from (S)-(-)-3-chloro-1-phenylpropanol by sequential reaction with sodium iodide, methylamine, sodium hydride, and 4-fluorobenzotrifluoride, (S)-Fluoxetine is dextrorotatory (+1.60) in methanol, but is levorotatory (-10.85) in water.
• Preparation: ...B. B. Malloy, K. K. Schmiegel, DE 2500110; B. B. Malloy, K. K. Schmiegel, US 4314081 (1975, 1982 both to Lilly)
• Breast Feeding; Lactation; Milk, Human; Antidepressive Agents; Serotonin Uptake Inhibitors

Synonyms

FLUOXETINE HYDROCHLORIDE; 56296-78-7; Fluoxetine Hcl; Adofen; Fluctin; Fluoxeren; Lovan; Fontex; Foxetin; Fluox-Puren; Fluneurin; Reconcile; Flusol; Affectine; Deproxin; Digassim

Frequently Asked Questions

What are the CAS number and molecular formula of fluoxetine hydrochloride?

CAS 59333-67-4; molecular formula C17H19ClF3NO; molecular weight — g/mol.

What other names is fluoxetine hydrochloride known by?

FLUOXETINE HYDROCHLORIDE, 56296-78-7, Fluoxetine Hcl, Adofen, Fluctin, Fluoxeren.

Is fluoxetine hydrochloride classified as hazardous?

0.8% of GHS notifications report no hazard classification (1 of 131).

What are the key physical properties of fluoxetine hydrochloride?

Melting Point: 158.4-158.9 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.