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Description

Fexofenadine · CAS 83799-24-0 · C32H39NO4. UNII E6582LOH6V. Melting Point: 142.5; Melting Point: 195-197 °C; Melting Point: 142.5 °C.

Identification

CAS Registry Number	83799-24-0
PubChem CID	3348
Molecular formula	C32H39NO4
IUPAC name	2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid
UNII (FDA)	E6582LOH6V

Computed Descriptors

Molecular Weight	501.7
XLogP3	3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	10
Exact Mass	501.28790873
Monoisotopic Mass	501.28790873
Topological Polar Surface Area	81
Heavy Atom Count	37
Formal Charge	0

Physical & Chemical Properties

Melting Point	142.5
Melting Point	195-197 °C
Melting Point	142.5 °C

Physical description & handling notes

• Solid
• Crystals from methanol-butanone
• Slightly soluble
• 226.9 Ų [M+H]+ [CCS Type: TW; Method: Major Mix IMS/Tof Calibration Kit (Waters)]
• 225.55 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 217.69 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Documented Uses

• Use (kg; approx.) in Germany (2009): >2500
• Consumption (g per capita; approx.) in Germany (2009): 0.0305
• Consumption (g per capita) in the USA (2002): 0.436
• An antihistamine drug used in the treatment of hayfever and similar allergy symptoms.
• In the United States, fexofenadine is indicated for the symptomatic treatment of allergic rhinitis in patients ≥2 years old and chronic idiopathic urticaria in patients ≥6 months old. In Canada, fexofenadine carries the same indications but is approved only for patients ≥12 years old. Fexofenadine is also available in combination with [pseudoephedrine] for the symptomatic treatment of season allergic rhinitis in patients ≥12 years old.
• Fexofenadine, a second-generation antihistamine, is a metabolite of terfenadine. The US Food and Drug Administration (FDA) approved fexofenadine to treat seasonal allergic rhinitis and chronic idiopathic urticaria. Fexofenadine is approved for use in both children and adults. Depending on the specific indications, children may be eligible for treatment starting at 6 months or older.

Synonyms

fexofenadine; 83799-24-0; Carboxyterfenadine; Terfenadine carboxylate; Terfenadine-COOH; Terfenadine acid metabolite; Telfast; MDL 16455; Fexofenadina; 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid; E6582LOH6V; 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid; 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid; 2-(4-{1-HYDROXY-4-[4-(HYDROXYDIPHENYLMETHYL)PIPERIDIN-1-YL]BUTYL}PHENYL)-2-METHYLPROPANOIC ACID; MDL-16455; CHEBI:5050

Frequently Asked Questions

What are the CAS number and molecular formula of Fexofenadine?

CAS 83799-24-0; molecular formula C32H39NO4; molecular weight — g/mol.

What other names is Fexofenadine known by?

fexofenadine, 83799-24-0, Carboxyterfenadine, Terfenadine carboxylate, Terfenadine-COOH, Terfenadine acid metabolite.

What are the key physical properties of Fexofenadine?

Melting Point: 142.5; Melting Point: 195-197 °C; Melting Point: 142.5 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.