酮替芬

Description

Ketotifen · CAS 34580-13-7 · C19H19NOS. UNII X49220T18G. Melting Point: 304 to 307 °F (NTP, 1992); Melting Point: 190; Melting Point: 152-153 °C.

Identification

CAS Registry Number	34580-13-7
PubChem CID	3827
Molecular formula	C19H19NOS
IUPAC name	2-(1-methylpiperidin-4-ylidene)-6-thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaen-8-one
UNII (FDA)	X49220T18G

Computed Descriptors

Molecular Weight	309.4
XLogP3	3.2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	0
Exact Mass	309.11873540
Monoisotopic Mass	309.11873540
Topological Polar Surface Area	48.6
Heavy Atom Count	22
Formal Charge	0

Physical & Chemical Properties

Melting Point	304 to 307 °F (NTP, 1992)
Melting Point	190
Melting Point	152-153 °C
Melting Point	191 °C (fumarate salt)
Solubility	7.87e-03 g/L
LogP	2.2
Dissociation Constants	8.43 ± 0.11

Physical description & handling notes

• Crystals (from ethyl acetate). (NTP, 1992)
• Solid
• Crystals from ethyl acetate
• Readily soluble
• In water, 15.3 mg/L at 25 °C /Estimated/
• 4.2X10-8 mm Hg at 25 °C /Estimated/

Regulatory Status

GHS notification summary	50% (1 / 2)

GHS Hazard Classification

GHS notification summary	50% (1 / 2)
Reported hazard statements	H302 (50%)

Documented Uses

• Preparation: J.P. Bourquin, DE 2111071 coresponding to US 3682930 (1971, 1972 both to Sandoz)
• Information available in 2004 indicated that Ketotifen was used in the manufacture of pharmaceutical preparations in the following countries: Algeria, Argentina, Bahrain, Brazil, Chile, Colombia, Dominican Republic, Ecuador, Egypt, Iraq, Jordan, Kuwait, Lebanon, Libyan Arab Jamahiriya, Luxembourg, New Zealand, Oman, Poland, Qatar, Romania, Saudi Arabia, Singapore, Spain, Sudan, Syrian Arab Republic, Thailand, Tunisia, Turkey, United Arab Emirates, Yemen, Yugoslavia
• Administered orally, ketotifen is indicated as an add-on medication in the chronic treatment of mild atopic asthma in children. It is also available as an over-the-counter ophthalmic solution which is indicated for the temporary prevention of itching of the eye due to allergic conjunctivitis.
• Breast Feeding; Lactation; Milk, Human; Anti-Allergic Agents; Antihistamines; Antipruritics
• Oral ketotifen is indicated as an add-on medication in the chronic treatment of mild atopic asthmatic children. Ketotifen is a prophylactic agent to be used on a continuous basis and is not effective in the acute prevention or treatment of acute asthma attacks. /Not commercially available in US/
• Ophthalmic ketotifen is indicated for the temporary prevention of itching of the eye due to allergic conjunctivitis. /Included in US product labeling/

Synonyms

ketotifen; 34580-13-7; Ketotifene; Ketotifeno; Ketotifenum; HC 20-511; DTXSID7023190; 4,9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one; X49220T18G; DTXCID203190; CHEBI:92511; 10H-Benzo[4,5]cyclohepta[1,2-b]thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-; 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-10h-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one; Ketotiphene; Ketotiphen; 10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one

Frequently Asked Questions

What are the CAS number and molecular formula of Ketotifen?

CAS 34580-13-7; molecular formula C19H19NOS; molecular weight — g/mol.

What other names is Ketotifen known by?

ketotifen, 34580-13-7, Ketotifene, Ketotifeno, Ketotifenum, HC 20-511.

Is Ketotifen classified as hazardous?

50% of GHS notifications report no hazard classification (1 of 2).

What are the key physical properties of Ketotifen?

Melting Point: 304 to 307 °F (NTP, 1992); Melting Point: 190; Melting Point: 152-153 °C; Melting Point: 191 °C (fumarate salt).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.