ketanserin

Description

ketanserin · CAS 74050-98-9 · C22H22FN3O3. UNII 97F9DE4CT4. LogP: 2.9.

Identification

CAS Registry Number	74050-98-9
PubChem CID	3822
Molecular formula	C22H22FN3O3
IUPAC name	3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione
UNII (FDA)	97F9DE4CT4

Computed Descriptors

Molecular Weight	395.4
XLogP3	2.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	395.16451973
Monoisotopic Mass	395.16451973
Topological Polar Surface Area	69.7
Heavy Atom Count	29
Formal Charge	0

Physical & Chemical Properties

LogP	2.9

Physical description & handling notes

• 191.99 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 184.73 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 196.47 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
• Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
• Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
• QC02K - Other antihypertensives
• QD03 - Preparations for treatment of wounds and ulcers

Synonyms

Ketanserin; 74050-98-9; Ketanserine; Ketanserinum; Ketanserina; Ketaserin; 3-(2-(4-(4-Fluorobenzoyl)piperidin-1-yl)ethyl)quinazoline-2,4(1H,3H)-dione; Serefrex; R-41468; DTXSID3023188; R-41,468; 3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione; R 41468; R 41,468; 97F9DE4CT4; 3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H,3H)-quinazolinedione

Frequently Asked Questions

What are the CAS number and molecular formula of ketanserin?

CAS 74050-98-9; molecular formula C22H22FN3O3; molecular weight — g/mol.

What other names is ketanserin known by?

Ketanserin, 74050-98-9, Ketanserine, Ketanserinum, Ketanserina, Ketaserin.

Is ketanserin classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of ketanserin?

LogP: 2.9.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.