氧氟沙星

Description

ofloxacin · CAS 82419-36-1 · C18H20FN3O4. UNII A4P49JAZ9H. Melting Point: 254; Melting Point: 250-257 °C (decomposes); Melting Point: 250 - 257 °C.

Identification

CAS Registry Number	82419-36-1
PubChem CID	4583
Molecular formula	C18H20FN3O4
IUPAC name	7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
UNII (FDA)	A4P49JAZ9H

Computed Descriptors

Molecular Weight	361.4
XLogP3	-0.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	2
Exact Mass	361.14378429
Monoisotopic Mass	361.14378429
Topological Polar Surface Area	73.3
Heavy Atom Count	26
Formal Charge	0

Physical & Chemical Properties

Melting Point	254
Melting Point	250-257 °C (decomposes)
Melting Point	250 - 257 °C
Solubility	28.3
Solubility	1.44e+00 g/L
LogP	-0.39
LogP	log Kow = -0.39
LogP	2.1
LogP	-0.05
Ionization Efficiency	3.3

Physical description & handling notes

• Solid
• Off-white to pale yellow crystalline powder
• Colorless needles from ethanol
• Soluble in aqueous solutions with pH between 2 and 5. Sparingly to slightly soluble in aqueous solutions with pH 7 (solubility falls to 4 mg/mL) and freely soluble in aqueous solutions with pH above 9.
• When heated to decomposition it emits toxic fumes of /hydrogen fluoride and nitrogen oxides/.
• Positive

Regulatory Status

GHS notification summary	23.1% (3 / 13)

GHS Hazard Classification

GHS notification summary	23.1% (3 / 13)
Reported hazard statements	H302 (85.2%), H312 (85.2%), H317 (85.2%), H332 (85.2%), H334 (85.2%), H341 (100%), H361 (14.8%), H315 (23.1%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >1000
• Use (kg; exact) in Germany (2009): 1202
• Use (kg) in France (2004): 4137
• Consumption (g per capita; approx.) in Germany (2009): 0.0122
• Consumption (g per capita; exact) in Germany (2009): 0.0147
• Consumption (g per capita) in France (2004): 0.0685

Synonyms

ofloxacin; 82419-36-1; Floxin; Ofloxacine; Tarivid; Ocuflox; Ofloxacino; Visiren; Ofloxacinum; DL-8280; Ofloxacina; Exocin; Hoe-280; Floxin otic; Ofloxacin Otic; OFLX

Frequently Asked Questions

What are the CAS number and molecular formula of ofloxacin?

CAS 82419-36-1; molecular formula C18H20FN3O4; molecular weight — g/mol.

What other names is ofloxacin known by?

ofloxacin, 82419-36-1, Floxin, Ofloxacine, Tarivid, Ocuflox.

Is ofloxacin classified as hazardous?

23.1% of GHS notifications report no hazard classification (3 of 13).

What are the key physical properties of ofloxacin?

Melting Point: 254; Melting Point: 250-257 °C (decomposes); Melting Point: 250 - 257 °C; Solubility: 28.3.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.