喹雌酚

Description

Quinestrol · CAS 152-43-2 · C25H32O2. UNII JR0N7XD5GZ. Melting Point: 107.5; Melting Point: 107.5 °C; Solubility: 1.57e-03 g/L.

Identification

CAS Registry Number	152-43-2
PubChem CID	9046
Molecular formula	C25H32O2
IUPAC name	(8R,9S,13S,14S,17R)-3-cyclopentyloxy-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol
UNII (FDA)	JR0N7XD5GZ

Computed Descriptors

Molecular Weight	364.5
XLogP3	5.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Exact Mass	364.240230259
Monoisotopic Mass	364.240230259
Topological Polar Surface Area	29.5
Heavy Atom Count	27
Formal Charge	0

Physical & Chemical Properties

Melting Point	107.5
Melting Point	107.5 °C
Solubility	1.57e-03 g/L

Physical description & handling notes

• Solid
• Quinestrol is the 3-cyclopentyl ether of ethinyl estradiol (the active metabolite). After gastrointestinal absorption, it is stored in adipose tissue where it is slowly released and metabolized principally to the parent compound, ethinyl estradiol. Ethinyl estradiol is a synthetic derivative of the natural estrogen estradiol.

GHS Hazard Classification

Reported hazard statements	H302 (60.9%), H312 (60.9%), H332 (60.9%), H350 (60.9%), H351 (39.1%), H360 (98.4%), H362 (37.5%)

Documented Uses

• Used in hormone replacement therapy, treating symptoms of menopause such as hot flashes. Also used to treat breast and prostate cancer.
• Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
• Absorbed following oral administration.
• Metabolized principally to the parent compound, ethinyl estradiol. Ethinyl estradiol is metabolized in the liver. Quantitatively, the major metabolic pathway for ethinyl estradiol, both in rats and in humans, is aromatic hydroxylation, as it is for the natural estrogens.

Synonyms

QUINESTROL; 152-43-2; Estrovis; Estrovister; Plestrovis; Eston; Estradiol-17-beta 3-cyclopentyl ether; Quinestrolum; Estrovis 4000; Quinestrolo; 17-alpha-Ethinylestradiol 3-cyclopentyl ether; Quilea; 17alpha-Ethynylestradiol 3-cyclopentyl ether; W 3566; W-3566; DTXSID6046553

Frequently Asked Questions

What are the CAS number and molecular formula of Quinestrol?

CAS 152-43-2; molecular formula C25H32O2; molecular weight — g/mol.

What other names is Quinestrol known by?

QUINESTROL, 152-43-2, Estrovis, Estrovister, Plestrovis, Eston.

Is Quinestrol classified as hazardous?

Hazard statements reported: H302, H312, H332, H350, H351.

What are the key physical properties of Quinestrol?

Melting Point: 107.5; Melting Point: 107.5 °C; Solubility: 1.57e-03 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.