Rabeprazole

Description

Rabeprazole · CAS 117976-89-3 · C18H21N3O3S. UNII 32828355LL. Melting Point: 99-100 °C (decomposes); Melting Point: 101.7 - 103.9 °C; LogP: 0.6.

Identification

CAS Registry Number	117976-89-3
PubChem CID	5029
Molecular formula	C18H21N3O3S
IUPAC name	2-[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methylsulfinyl]-1H-benzimidazole
UNII (FDA)	32828355LL

Computed Descriptors

Molecular Weight	359.4
XLogP3	1.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	8
Exact Mass	359.13036271
Monoisotopic Mass	359.13036271
Topological Polar Surface Area	96.3
Heavy Atom Count	25
Formal Charge	0

Physical & Chemical Properties

Melting Point	99-100 °C (decomposes)
Melting Point	101.7 - 103.9 °C
LogP	0.6

Physical description & handling notes

• Solid
• White crystals from CH2Cl2/ether
• 2.2X10-15 mm Hg at 25 °C /Estimated/
• log Kow = 1.17 /Estimated/
• Henry's Law constant: 1.2X10-17 atm-cu m/mole at 25 °C /Estimated/
• 187.8 Ų [M]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID3044205]

GHS Hazard Classification

Reported hazard statements	H315 (92.9%), H319 (92.9%), H335 (92.9%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >250
• Consumption (g per capita; approx.) in Germany (2009): 0.00305
• Consumption (g per capita) in the USA (2002): 0.0222
• Preparation B. Roques et al., EP 38758 (1981); eidem US 4513009 (1988, 1991 both to Eisai)
• For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
• Rabeprazole is a proton pump inhibitor (PPI) and a potent inhibitor of gastric acidity used in the therapy of gastroesophageal reflux and peptic ulcer disease. Rabeprazole therapy is associated with a low rate of transient and asymptomatic serum aminotransferase elevations and is a rare cause of clinically apparent liver injury.

Synonyms

rabeprazole; 117976-89-3; pariprazole; Eraloc; rabeprazol; LY307640; 2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]-1H-benzimidazole; LY-307640; CHEBI:8768; 32828355LL; E-3810 (PPI); 2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole; 1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-; LY 307640; DTXCID1024122; DTXSID3044122

Frequently Asked Questions

What are the CAS number and molecular formula of Rabeprazole?

CAS 117976-89-3; molecular formula C18H21N3O3S; molecular weight — g/mol.

What other names is Rabeprazole known by?

rabeprazole, 117976-89-3, pariprazole, Eraloc, rabeprazol, LY307640.

Is Rabeprazole classified as hazardous?

Hazard statements reported: H315, H319, H335.

What are the key physical properties of Rabeprazole?

Melting Point: 99-100 °C (decomposes); Melting Point: 101.7 - 103.9 °C; LogP: 0.6.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.