5-羟色胺酸

Description

5-HTP · CAS 56-69-9 · C11H12N2O3. UNII 9181P3OI6N. Melting Point: 298-300 °C (decomposes); Solubility: In water, 1X10+4 mg/L at 5 °C.

Identification

CAS Registry Number	56-69-9
PubChem CID	144
Molecular formula	C11H12N2O3
IUPAC name	2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
UNII (FDA)	9181P3OI6N

Computed Descriptors

Molecular Weight	220.22
XLogP3	-1.2
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	220.08479225
Monoisotopic Mass	220.08479225
Topological Polar Surface Area	99.3
Heavy Atom Count	16
Formal Charge	0

Physical & Chemical Properties

Melting Point	298-300 °C (decomposes)
Solubility	In water, 1X10+4 mg/L at 5 °C

Physical description & handling notes

• Minute rods or needles from ethanol
• MP: 273 °C (decomposes); specific optical rotation: +16.0 deg at 22 °C (c=1 in 4M HCl); -32 deg at 22 °C (c=1 in H2O) /(S)-5-Hydroxytryptophan/
• Solubilities: 2.5 g/100 mL in 50% boiling alcohol; 5.5 g/100 mL in water at 100 °C
• AQ SOLN ARE STABLE @ LOW PH /DL-FORM/
• 149.2 Ų [M-H]- [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
• 152.2 Ų [M+Na]+ [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]

Regulatory Status

Regulatory & Food Contact	Hydroxytryptophan (5-HTP)

GHS Hazard Classification

Reported hazard statements	H226 (33.3%), H301 (33.3%), H302 (66.7%), H319 (33.3%), H332 (33.3%)

Documented Uses

• Antidepressant; in treatment of myoclonus
• For use as an antidepressant, appetite suppressant, and sleep aid.
• MANNICH CONDENSATION OF 5-BENZYLOXYINDOLE; CATALYTIC HYDROGENOLYSIS OF 5-BENZYLOXYTRYPTOPHAN; ENZYMATIC HYDROXYLATION OF TRYPTOPHAN
• (1979) NOT PRODUCED COMMERCIALLY IN US
• Tryptophan, 5-hydroxy-: INACTIVE
• 5-HTP has shown some usefulness in some conditions characterized, in part, by serotonin deficits, principally depression. It has also been shown to be useful in some with obesity, insomnia, fibromyalgia and chronic tension headache.

Synonyms

5-hydroxytryptophan; 56-69-9; 114-03-4; 5-HTP; DL-5-HTP; (+-)-5-Hydroxytryptophan; Tryptophan, 5-hydroxy-; 9181P3OI6N; CHEBI:28171; DTXSID50859863; 5 Hydroxytryptophan; 2-azaniumyl-3-(5-hydroxy-1H-indol-3-yl)propanoate; Tryptophan, 5 Hydroxy; 5-hydroxytryptophan DL-; RefChem:905501; DTXCID90208816

Frequently Asked Questions

What are the CAS number and molecular formula of 5-HTP?

CAS 56-69-9; molecular formula C11H12N2O3; molecular weight — g/mol.

What other names is 5-HTP known by?

5-hydroxytryptophan, 56-69-9, 114-03-4, 5-HTP, DL-5-HTP, (+-)-5-Hydroxytryptophan.

What is the regulatory status of 5-HTP?

Documented regulatory listings: Hydroxytryptophan (5-HTP).

Is 5-HTP classified as hazardous?

Hazard statements reported: H226, H301, H302, H319, H332.

What are the key physical properties of 5-HTP?

Melting Point: 298-300 °C (decomposes); Solubility: In water, 1X10+4 mg/L at 5 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.