氟甲睾酮

Description

Fluoxymesterone · CAS 76-43-7 · C20H29FO3. UNII 9JU12S4YFY. Melting Point: 265; Melting Point: 270 °C; Solubility: 67.5.

Identification

CAS Registry Number	76-43-7
PubChem CID	6446
Molecular formula	C20H29FO3
IUPAC name	(8S,9R,10S,11S,13S,14S,17S)-9-fluoro-11,17-dihydroxy-10,13,17-trimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
UNII (FDA)	9JU12S4YFY

Computed Descriptors

Molecular Weight	336.4
XLogP3	2.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Exact Mass	336.21007294
Monoisotopic Mass	336.21007294
Topological Polar Surface Area	57.5
Heavy Atom Count	24
Formal Charge	0

Physical & Chemical Properties

Melting Point	265
Melting Point	270 °C
Solubility	67.5
Solubility	4.52e-02 g/L
LogP	2.38
LogP	log Kow = 2.38
Other Experimental Properties	Decomposes at 270 °C

Physical description & handling notes

• Solid
• Crystals
• WHITE SOLID
• White or practically white crystalline powder
• ODORLESS
• TASTELESS

GHS Hazard Classification

Reported hazard statements	H361 (97.6%)

Documented Uses

• In males, used as replacement therapy in conditions associated with symptoms of deficiency or absence of endogenous testosterone. In females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal.
• PREPARATION ... CF HERR, US PATENT 2813881 (1957 TO UPJOHN).
• From 17-methyltestosterone first by introduction of hydroxyl group at position 11 through oxidation with microorganism (such as pestalotia or aspergillus), followed by dehydration, epoxidation & treatment with mercury ...
• Prepared from 17-alpha-methyltestosterone by conversion into the 11-alpha- hydroxy derivative by microbiological oxidation with Rhizopus; tosylation at C-11, followed by elimination ... yields the 9,11-ene; addition of hypobromous acid ... /yields/ the 9-beta, 11-beta-epoxide; hydrogen fluoride fission of the epoxide ring yields fluoxymesterone
• Inactive ingredients in pharmaceutical tablets: calcium stearate, corn starch, FD&C yellow no 5, lactose, sorbic acid, sucrose, tragacanth...in addition, FD&C yellow no 6 ... FD&C no 2
• While data specific to fluosymestrone were not located(SRC, 2005), the literature suggests that some pharmaceutically active compounds originating from human and veterinary therapy are not eliminated completely in municipal sewage treatment plants and are therefore discharged into receiving waters(1). Wastewater treatment processes often were not designed to remove them from the effluent(2). Selected organic waste compounds may be degrading to new and more persistent compounds that may be released instead of or in

Synonyms

fluoxymesterone; 76-43-7; Halotestin; Fluoxymestrone; Androfluorene; Androfluorone; Fluoximesterone; Fluotestin; Oratestin; Ultandren; Testoral; Android-f; Ora-Testryl; Androsterolo; Flusteron; Flutestos

Frequently Asked Questions

What are the CAS number and molecular formula of Fluoxymesterone?

CAS 76-43-7; molecular formula C20H29FO3; molecular weight — g/mol.

What other names is Fluoxymesterone known by?

fluoxymesterone, 76-43-7, Halotestin, Fluoxymestrone, Androfluorene, Androfluorone.

Is Fluoxymesterone classified as hazardous?

Hazard statements reported: H361.

What are the key physical properties of Fluoxymesterone?

Melting Point: 265; Melting Point: 270 °C; Solubility: 67.5; Solubility: 4.52e-02 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.