非氨酯

Description

Felbamate · CAS 25451-15-4 · C11H14N2O4. UNII X72RBB02N8. Melting Point: 151.5; Melting Point: 151-153 °C; Melting Point: 151.5 °C.

Identification

CAS Registry Number	25451-15-4
PubChem CID	3331
Molecular formula	C11H14N2O4
IUPAC name	(3-carbamoyloxy-2-phenylpropyl) carbamate
UNII (FDA)	X72RBB02N8

Computed Descriptors

Molecular Weight	238.24
XLogP3	0.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	7
Exact Mass	238.09535693
Monoisotopic Mass	238.09535693
Topological Polar Surface Area	105
Heavy Atom Count	17
Formal Charge	0

Physical & Chemical Properties

Melting Point	151.5
Melting Point	151-153 °C
Melting Point	151.5 °C
Solubility	7.42e-01 g/L
LogP	0.3

Physical description & handling notes

• Solid
• White powder
• Odorless
• Slightly soluble in water
• Sparingly soluble in water, methanol, ethanol, acetone and chloroform; freely soluble in DSMO, 1-methyl-2-pyrrolidinone and DMF.
• When heated to decomposition it emits toxic vapors of /nitrogen oxides/.

Regulatory Status

GHS notification summary	2.2% (1 / 45)

GHS Hazard Classification

GHS notification summary	2.2% (1 / 45)
Reported hazard statements	H317 (95.6%), H334 (95.6%)

Documented Uses

• Use (kg; approx.) in Germany (2009): >100
• Consumption (g per capita; approx.) in Germany (2009): 0.00122
• For use only in those patients who respond inadequately to alternative treatments and whose epilepsy is so severe that a substantial risk of aplastic anemia and/or liver failure is deemed acceptable in light of the benefits conferred by its use.
• 2-Phenyl-1,3-propanediole is reacted with ethylcarbamate to yield felbamate.
• Felbamate is a dicarbamate derivative anticonvulsant that is typically used in combination with other antiepileptic medications for refractory partial onset or generalized seizures. Felbamate has been associated with multiple cases of aplastic anemia and acute liver failure and its use is now restricted.
• Breast Feeding; Lactation; Anticonvulsants

Synonyms

felbamate; 25451-15-4; Felbatol; 2-Phenyl-1,3-propanediol dicarbamate; Taloxa; Felbamato; Felbamatum; W-554; 1,3-Propanediol, 2-phenyl-, dicarbamate; ADD-03055; DTXSID9023041; W 554; carbamic acid 2-phenyltrimethylene ester; Carbamic acid, 2-phenyltrimethylene ester; 3-(carbamoyloxy)-2-phenylpropyl carbamate; NSC-759866

Frequently Asked Questions

What are the CAS number and molecular formula of Felbamate?

CAS 25451-15-4; molecular formula C11H14N2O4; molecular weight — g/mol.

What other names is Felbamate known by?

felbamate, 25451-15-4, Felbatol, 2-Phenyl-1,3-propanediol dicarbamate, Taloxa, Felbamato.

Is Felbamate classified as hazardous?

2.2% of GHS notifications report no hazard classification (1 of 45).

What are the key physical properties of Felbamate?

Melting Point: 151.5; Melting Point: 151-153 °C; Melting Point: 151.5 °C; Solubility: 7.42e-01 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.