甲磺酸非诺多泮

Description

Fenoldopam Mesylate · CAS 67227-57-0 · C16H16ClNO3. UNII INU8H2KAWG. Solubility: 4000; Solubility: 2.72e-01 g/L; LogP: 1.53.

Identification

CAS Registry Number	67227-57-0
PubChem CID	3341
Molecular formula	C16H16ClNO3
IUPAC name	9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
UNII (FDA)	INU8H2KAWG

Computed Descriptors

Molecular Weight	305.75
XLogP3	2.4
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	305.0818711
Monoisotopic Mass	305.0818711
Topological Polar Surface Area	72.7
Heavy Atom Count	21
Formal Charge	0

Physical & Chemical Properties

Solubility	4000
Solubility	2.72e-01 g/L
LogP	1.53

Physical description & handling notes

• Solid
• Fenoldopam is an agonist at D₁-like dopamine receptors, binds to α₂-adrenoceptors, increasing renal blood flow.

Documented Uses

• For the in-hospital, short-term (up to 48 hours) management of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function.
• Breast Feeding; Lactation; Milk, Human; Antihypertensive Agents; Dopamine Agents; Dopamine Agonists; Vasodilator Agents
• Take on an empty stomach. Orally administered fenoldopam should be taken in a fasted state for optimal absorption.
• Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
• Drugs used to cause dilation of the blood vessels.
• Drugs that bind to and activate dopamine receptors.

Synonyms

fenoldopam; 67227-56-9; Fenoldopamum; Carlacor; SKF 82526; 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol; DTXSID0043896; INU8H2KAWG; CHEBI:5002; SK&F-82526J; DTXCID8023896; SKF-82526; 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-; RefChem:56465; SKF82526J; C01CA19

Frequently Asked Questions

What are the CAS number and molecular formula of Fenoldopam Mesylate?

CAS 67227-57-0; molecular formula C16H16ClNO3; molecular weight — g/mol.

What other names is Fenoldopam Mesylate known by?

fenoldopam, 67227-56-9, Fenoldopamum, Carlacor, SKF 82526, 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol.

What are the key physical properties of Fenoldopam Mesylate?

Solubility: 4000; Solubility: 2.72e-01 g/L; LogP: 1.53.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.