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Description

Gefapixant · CAS 1015787-98-0 · C14H19N5O4S. UNII 6K6L7E3F1L. Solubility: 140.

Identification

CAS Registry Number	1015787-98-0
PubChem CID	24764487
Molecular formula	C14H19N5O4S
IUPAC name	5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide
UNII (FDA)	6K6L7E3F1L

Computed Descriptors

Molecular Weight	353.40
XLogP3	0.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	5
Exact Mass	353.11577528
Monoisotopic Mass	353.11577528
Topological Polar Surface Area	165
Heavy Atom Count	24
Formal Charge	0

Physical & Chemical Properties

Solubility	140

GHS Hazard Classification

Reported hazard statements	H373 (94.7%)

Documented Uses

• Gefapixant is indicated in adult patients for the treatment of refractory or unexplained chronic cough.
• Take with or without food. The administration of gefapixant with food does not result in clinically significant differences in its pharmacokinetics.
• R05 - Cough and cold preparations
• R05D - Cough suppressants, excl. combinations with expectorants
• R05DB - Other cough suppressants
• QR05 - Cough and cold preparations

Synonyms

Gefapixant; 1015787-98-0; AF-219; Ro-4926219; RO4926219; RG-1646; 5-[(2,4-diaminopyrimidin-5-yl)oxy]-2-methoxy-4-(propan-2-yl)benzene-1-sulfonamide; Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-; 6K6L7E3F1L; R-1646; 5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide; DTXSID401337212; Benzenesulfonamide, 5-((2,4-diamino-5-pyrimidinyl)oxy)-2-methoxy-4-(1-methylethyl)-; gefapixantum; 5-((2,4-diaminopyrimidin-5-yl)oxy)-2-methoxy-4-(propan-2-yl)benzene-1-sulfonamide; RefChem:639790

Frequently Asked Questions

What are the CAS number and molecular formula of Gefapixant?

CAS 1015787-98-0; molecular formula C14H19N5O4S; molecular weight — g/mol.

What other names is Gefapixant known by?

Gefapixant, 1015787-98-0, AF-219, Ro-4926219, RO4926219, RG-1646.

Is Gefapixant classified as hazardous?

Hazard statements reported: H373.

What are the key physical properties of Gefapixant?

Solubility: 140.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.