格拉普兰特

格拉普兰特（CAS 415903-37-6）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• >136 ºC (Grapiprant hydrochloride)
• Insoluble
• Preclinical studies have shown that grapiprant is very effective to reduce acute and chronic pain and inflammation. The effect of grapiprant seems to be dose-dependent and it is comparable to the effect of rofecoxib and piroxicam. The effects of grapiprant have been reported to be effective in the relief from arthritic pain in canine patients.

公开数据库收录的理化数据

这个物质在各数据库里的编号

数据库记载的用途

• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• QM01 - Antiinflammatory and antirheumatic products
• QM01A - Antiinflammatory and antirheumatic products, non-steroids
• QM01AX - Other antiinflammatory and antirheumatic agents, non-steroids
• Studies in animals (horse) have shown the presence of a concentration >0.005 ng/ml in serum 72 hours after initial administration of a dose of 2 mg/kg. It is rapidly absorbed and the reported Cmax in this reports was 31.9 ng/ml in a Tmax of 1.5 hours and AUC of 2000 ng.hr/ml. In the case of bioavailability, grapiprant presents a mean bioavailability of 39%. The bioavailability, time for peak concentration and maximal concentration has been reported to be significantly reduced after food.
• Following an oral dose, the majority of the dose an within the first 72 hours. Studies in animals (horse) have shown the presence of a concentration >0.005 ng/ml in urine 96 hours after initial administration of a dose of 2 mg/kg. From the excreted dose, 55%, 15% and 19% of the administered dose is excreted in bile, urine, and feces respectively.

它在各数据库里的别名

Grapiprant; 415903-37-6; CJ-023423; CJ 023423; CJ-023,423; AAT-007; MR-10A7; CJ-023; MR10A7; RQ-00000007; J9F5ZPH7NB; 1-[2-[4-(2-ethyl-4,6-dimethylimidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea; DTXSID60194419; 1-(2-(4-(2-ethyl-4,6-dimethylimidazo(4,5-c)pyridin-1-yl)phenyl)ethyl)-3-(4-methylphenyl)sulfonylurea; grapiprantum; Galliprant

计算机算出的分子描述符

数据库摘要

Grapiprant · CAS 415903-37-6 · C26H29N5O3S. UNII J9F5ZPH7NB. LogP: 4.56.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。