17-丁酸氢化可的松

Description

hydrocortisone 17-butyrate · CAS 13609-67-1 · C25H36O6. UNII 05RMF7YPWN. LogP: 3.18.

Identification

CAS Registry Number	13609-67-1
PubChem CID	26133
Molecular formula	C25H36O6
IUPAC name	[(8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] butanoate
UNII (FDA)	05RMF7YPWN

Computed Descriptors

Molecular Weight	432.5
XLogP3	3.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	432.25118886
Monoisotopic Mass	432.25118886
Topological Polar Surface Area	101
Heavy Atom Count	31
Formal Charge	0

Physical & Chemical Properties

LogP	3.18

Regulatory Status

GHS notification summary	16.7% (1 / 6)

GHS Hazard Classification

GHS notification summary	16.7% (1 / 6)
Reported hazard statements	H302, H312, H332 (16.7%), H315 (33.3%), H319 (33.3%), H341 (16.7%), H361 (16.7%), H373 (16.7%)

Documented Uses

• For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
• Drugs used to treat or prevent skin disorders or for the routine care of skin.
• Corticosteroid Hormone Receptor Agonists [MoA]; Corticosteroid [EPC]
• D07 - Corticosteroids, dermatological preparations
• D07AB - Corticosteroids, moderately potent (group ii)
• D07AB02 - Hydrocortisone butyrate

Synonyms

hydrocortisone butyrate; Hydrocortisone 17-butyrate; 13609-67-1; Cortisol 17-butyrate; Locoid; Hydrocortisone-17-butyrate; Hydrocortisone-17alpha-butyrate; Locoid Lipocream; 17-O-butyrylcortisol; DTXSID4045896; 05RMF7YPWN; H-17-B; 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate; CHEBI:31674; NSC-758433; 11beta,21-dihydroxy-3,20-dioxopregn-4-en-17-yl butanoate

Frequently Asked Questions

What are the CAS number and molecular formula of hydrocortisone 17-butyrate?

CAS 13609-67-1; molecular formula C25H36O6; molecular weight — g/mol.

What other names is hydrocortisone 17-butyrate known by?

hydrocortisone butyrate, Hydrocortisone 17-butyrate, 13609-67-1, Cortisol 17-butyrate, Locoid, Hydrocortisone-17-butyrate.

Is hydrocortisone 17-butyrate classified as hazardous?

16.7% of GHS notifications report no hazard classification (1 of 6).

What are the key physical properties of hydrocortisone 17-butyrate?

LogP: 3.18.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.