Levamisole Hydrochloride

Description

Levamisole Hydrochloride · CAS 16595-80-5 · C11H12N2S.ClH. UNII DL9055K809. Solubility: Water 210 (mg/mL); Optical Rotation: (c = 1, H2O) [a]21D = - 126.2 ± 1.4°.

Identification

CAS Registry Number	16595-80-5
PubChem CID	27944
Molecular formula	C11H12N2S.ClH
IUPAC name	(6S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole;hydrochloride
UNII (FDA)	DL9055K809

Computed Descriptors

Molecular Weight	240.75
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	240.0487973
Monoisotopic Mass	240.0487973
Topological Polar Surface Area	40.9
Heavy Atom Count	15
Formal Charge	0
Complexity	246

Physical & Chemical Properties

Solubility	Water 210 (mg/mL)
Optical Rotation	(c = 1, H2O) [a]21D = - 126.2 ± 1.4°

Physical description & handling notes

• Methanol sol. (mg/mL)
• Propylene glycol sol. (mg/mL)
• Ethanol sl. sol. (mg/mL)
• >36.1 [ug/mL] (The mean of the results at pH 7.4)
• Bulk: Levamisole appears to be stable in the bulk form at 60°C for at least four weeks. Solution: At 100 mg/mL concentrations in water and pH 7 buffer, the compound is stable for at least 9 days when stored at ambient temperature under normal laboratory illumination.
• 143.9 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

Regulatory & Food Contact	ANTHELMINTHIC_AGENT: Veterinary Drug 0-6 µg/kg bw TRS 851-JECFA 42/7 FAS 33-JECFA 42/3 NEMICIDE WORM-CHEK

GHS Hazard Classification

Reported hazard statements	H301 (100%), H361 (22.4%), H373 (20.7%), H412 (23.6%), H372

Documented Uses

• Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
• Veterinary Drug -> ANTHELMINTHIC_AGENT -> JECFA Functional Classes
• Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune
• Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.
• Drugs that are used to treat RHEUMATOID ARTHRITIS.

Synonyms

Levamisole hydrochloride; 16595-80-5; Levamisole HCl; Ergamisol; Ascaridil; Tramisol; Decaris; Levasole; Solaskil; NSC-177023; Spartakon l; L-narpenol; R 12,564; DTXSID7047518; L-Tetramisole hydrochloride; R 12564

Frequently Asked Questions

What are the CAS number and molecular formula of Levamisole Hydrochloride?

CAS 16595-80-5; molecular formula C11H12N2S.ClH; molecular weight — g/mol.

What other names is Levamisole Hydrochloride known by?

Levamisole hydrochloride, 16595-80-5, Levamisole HCl, Ergamisol, Ascaridil, Tramisol.

What is the regulatory status of Levamisole Hydrochloride?

Documented regulatory listings: ANTHELMINTHIC_AGENT: Veterinary Drug; 0-6 µg/kg bw; TRS 851-JECFA 42/7.

Is Levamisole Hydrochloride classified as hazardous?

Hazard statements reported: H301, H361, H373, H412, H372.

What are the key physical properties of Levamisole Hydrochloride?

Solubility: Water 210 (mg/mL); Optical Rotation: (c = 1, H2O) [a]21D = - 126.2 ± 1.4°.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.