盐酸拉贝洛尔

Description

labetalol hydrochloride · CAS 32780-64-6 · C19H25ClN2O3. UNII 1GEV3BAW9J.

Identification

CAS Registry Number	32780-64-6
PubChem CID	71412
Molecular formula	C19H25ClN2O3
IUPAC name	2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide;hydrochloride
UNII (FDA)	1GEV3BAW9J

Computed Descriptors

Molecular Weight	364.9
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	8
Exact Mass	364.1553704
Monoisotopic Mass	364.1553704
Topological Polar Surface Area	95.6
Heavy Atom Count	25
Formal Charge	0
Complexity	385

Physical description & handling notes

• 177.6 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS notification summary	3.4% (2 / 59)

GHS Hazard Classification

GHS notification summary	3.4% (2 / 59)
Reported hazard statements	H302 (93.2%), H315 (91.5%), H319 (91.5%), H335 (91.5%), H411 (91.5%)

Documented Uses

• Breast Feeding; Lactation; Milk, Human; Antihypertensive Agents; Adrenergic Beta-Antagonists; Antiarrhythmics
• Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
• Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
• Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
• Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS.
• Adrenergic beta-Antagonists [MoA]; beta-Adrenergic Blocker [EPC]

Synonyms

Labetalol hydrochloride; 32780-64-6; Labetalol HCL; Labrocol; ScH 15719W; AH 5158A; Ibidomide hydrochloride; Sch-15719W; DTXSID0044654; 1GEV3BAW9J; AH-5158A; NSC-290312; AH-5158A HYDROCHLORIDE; SCH-15719W HYDROCHLORIDE; DTXCID8024654; NSC290312

Frequently Asked Questions

What are the CAS number and molecular formula of labetalol hydrochloride?

CAS 32780-64-6; molecular formula C19H25ClN2O3; molecular weight — g/mol.

What other names is labetalol hydrochloride known by?

Labetalol hydrochloride, 32780-64-6, Labetalol HCL, Labrocol, ScH 15719W, AH 5158A.

Is labetalol hydrochloride classified as hazardous?

3.4% of GHS notifications report no hazard classification (2 of 59).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.