莱特莫韦

莱特莫韦（CAS 917389-32-3）的公开数据库记录，列此仅供独立核对。

危险化学品分类与危害说明

物理形态与操作说明

• Letermovir inhibits the activity of the DNA terminase complex of CMV thereby preventing the cutting of viral DNA into mature length genomes for packaging into viral particles. Letemovir inhibits the DNA terminase complex with an EC50 of 2.1nM.

这个物质在各数据库里的编号

数据库记载的用途

• Letermovir is indicated for prophylaxis against cytomegalovirus (CMV) infection and disease in recipients, ≥6 months of age and ≥6 kg, of an allogeneic hematopoietic stem cell transplant (HSCT) who are CMV-seropositive. It is also indicated for prophylaxis against CMV disease in kidney transplant recipients, ≥12 years of age and ≥40 kg, who are at risk (i.e. donor CMV-seropositive/recipient CMV-seronegative).
• Letermovir is an antiviral agent which targets the DNA terminal transferase complex of the cytomegalovirus (CMV) and which is used to prevent CMV reactivation in immunocompromised patients. Letermovir has been associated with mild-to-moderate serum aminotransferase elevations during therapy but has not been linked to cases of clinically apparent acute liver injury.
• Breast Feeding; Lactation; Anti-Infective Agents; Antiviral Agents;
• Avoid St. John's Wort. Co-administration may lead to decreased serum concentrations of letermovir.
• Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
• Chemicals and drugs that inhibit the action of POLY(ADP-RIBOSE)POLYMERASES.

它在各数据库里的别名

Letermovir; 917389-32-3; Prevymis; AIC246; AIC-246; AIC 246; MK-8228; 1H09Y5WO1F; DTXSID40238683; letermovirum; RefChem:57199; DTXCID90161174; J05AX18; 805-689-9; UNII-1H09Y5WO1F; MFCD22572725

计算机算出的分子描述符

数据库摘要

Letermovir · CAS 917389-32-3 · C29H28F4N4O4. UNII 1H09Y5WO1F.

数据来源：PubChem / Wikidata；与随货 COA 不一致时以 COA 为准。