美托拉宗

Name: 美托拉宗
Brand: 济南圣和化工有限公司

CAS 17560-51-9C16H16ClN3O3SMW 365.8

美托拉宗，CAS 登记号 17560-51-9，由济南圣和化工有限公司现货供应，可提供纯度按批次COA提供(不公开发布) 的规格，下游主要用于有机化学品。支持样品与小批量试用，批量价格请联系我们获取，验收以批次 COA 为准。

规格参数

CAS号17560-51-9

分子式C16H16ClN3O3S

分子量365.8

熔点256

LogP2.5

纯度按批次COA提供(不公开发布)

包装按订单/批次确认(不公开发布)

应用领域有机化学品

类别有机化学品

用途与场景

有机化学品

包装与供货

包装规格按订单/批次确认(不公开发布)

纯度规格按批次COA提供(不公开发布)

储存条件密封、阴凉干燥处保存

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主要涉及有机化学品。

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PubChem 公开数据

Description

Metolazone · CAS 17560-51-9 · C16H16ClN3O3S. UNII NM7V2Y3G0U. Melting Point: 256; Melting Point: 253-259 °C; Melting Point: 256 °C.

Identification

CAS Registry Number	17560-51-9
PubChem CID	4170
Molecular formula	C16H16ClN3O3S
IUPAC name	7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide
UNII (FDA)	NM7V2Y3G0U

Computed Descriptors

Molecular Weight	365.8
XLogP3	4.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	365.0600902
Monoisotopic Mass	365.0600902
Topological Polar Surface Area	101
Heavy Atom Count	24
Formal Charge	0

Physical & Chemical Properties

Melting Point	256
Melting Point	253-259 °C
Melting Point	256 °C
Solubility	60.3
Solubility	4.07e-02 g/L
LogP	2.5
LogP	1.8
Dissociation Constants	PKA: 9.72

Physical description & handling notes

Solid
CRYSTALS FROM ETHANOL
ODORLESS
TASTELESS
INSOL IN WATER & ALCOHOL
LIGHT-SENSITIVE

GHS Hazard Classification

Reported hazard statements	H315 (100%), H319 (100%), H335 (100%)

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Documented Uses

SHETTY, US PATENTS 3,360,518 (1967 TO WALLACE & TIERNAN) AND 3,557,111 (1971); SHETTY ET AL, J MED CHEM 13, 886 (1970).
5-CHLORO-O-TOLUIDINE IS CONVERTED THROUGH SERIES OF REACTIONS INTO N-(O-TOLYL)-2-AMINO-4-CHLORO-5-SULFAMOYLBENZAMIDE WHICH IS CAUSED TO UNDERGO RING CLOSURE THROUGH REACTION WITH ACETALDEHYDE. US PATENT 3,360,518.
For the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class.
Breast Feeding; Lactation; Milk, Human; Antihypertensive Agents; Thiazide Diuretics
Antihypertensive Agents; Diuretics, Sulfamyl
DIURETIC & ANTIHYPERTENSIVE DRUG. ... METOLAZONE IS INDICATED FOR EDEMA ACCOMPANYING CONGESTIVE HEART FAILURE, RENAL DISEASE INCL NEPHROTIC SYNDROME, & OTHER CONDITIONS OF DIMINISHED RENAL FUNCTION.

Synonyms

metolazone; 17560-51-9; Zaroxolyn; Diulo; Mykrox; Oldren; Metenix; Metalozone; Metolazona; Metolazonum; metozalone; Normelan; Xuret; SR 720-22; 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide; SR-720-22

Frequently Asked Questions

What are the CAS number and molecular formula of Metolazone?

CAS 17560-51-9; molecular formula C16H16ClN3O3S; molecular weight — g/mol.

What other names is Metolazone known by?

metolazone, 17560-51-9, Zaroxolyn, Diulo, Mykrox, Oldren.

Is Metolazone classified as hazardous?

Hazard statements reported: H315, H319, H335.

What are the key physical properties of Metolazone?

Melting Point: 256; Melting Point: 253-259 °C; Melting Point: 256 °C; Solubility: 60.3.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.

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