盐酸马法兰

Description

Melphalan hydrochloride · CAS 3223-07-2 · C13H19Cl3N2O2. UNII 1VXP4V453T. Solubility: 95% ethanol <0.9 (mg/mL); Solubility: Methanol 2.8 - 5.6 (mg/mL); Solubility: Water 1.7 - 2.3 (mg/mL).

Identification

CAS Registry Number	3223-07-2
PubChem CID	9927978
Molecular formula	C13H19Cl3N2O2
IUPAC name	(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid;hydrochloride
UNII (FDA)	1VXP4V453T

Computed Descriptors

Molecular Weight	341.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	8
Exact Mass	340.051211
Monoisotopic Mass	340.051211
Topological Polar Surface Area	66.6
Heavy Atom Count	20
Formal Charge	0
Complexity	265

Physical & Chemical Properties

Solubility	95% ethanol <0.9 (mg/mL)
Solubility	Methanol 2.8 - 5.6 (mg/mL)
Solubility	Water 1.7 - 2.3 (mg/mL)
Solubility	Chloroform <1 (mg/mL)
Solubility	0.1NHCL 9-17 (mg/mL)
Solubility	0.1 N NaOH 7-10.6 (mg/mL)
Solubility	Acetone <1 (mg/mL)

Physical description & handling notes

• 10% aqueous ethanol 1.3 (mg/mL)
• pH 4 citrate buffer 2.2 - 2.6 (mg/mL)
• pH 9 borate buffer 2.0 - 2.4 (mg/mL)
• Bulk: A dried sample, stored at 60 °C for 15 days, showed about 10% decomposition as indicated by UV absorption and ionic chloride content. Solution: After 24 hours in water at 28 °C, approximately 80% decomposition was observed (TLC).
• (c = 0.7, methanol on a dried basis) [a]24 D = -31.5 ± 2°

GHS Hazard Classification

Reported hazard statements	H300, H310, H330 (16.7%), H317 (16.7%), H340 (100%), H350 (100%), H360 (16.7%), H361 (66.7%)

Documented Uses

• Alkeran for Injection (Melphalan Hydrochloride)
• Melphalan hydrochloride is approved to treat:
• • Multiple myeloma. This use is approved for the Evomela brand of melphalan hydrochloride.
• • It is used as palliative treatment in patients who cannot take the tablet form of melphalan.
• • It is used as a conditioning treatment to prepare patients for a stem cell transplant.
• • Uveal melanoma that has spread to the liver and cannot be removed by surgery. It is used in adults whose liver metastases affect less than half of the liver and either the cancer has not spread to other areas of the body or it has spread to the bone, lymph nodes, subcutaneous tissue, or lungs and these metastases can be treated by surgery or radiation therapy. This use is approved for the Hepzato brand of melphalan hydrochloride.

Synonyms

Melphalan hydrochloride; 3223-07-2; Melphalan HCl; Alkeran hydrochloride; CB 3025 hydrochloride; Evomela; Phenylalanine mustard hydrochloride; L-Sarcolysine hydrochloride; Sarcolysin hydrochloride, l-; 1VXP4V453T; Melfalan hydrochloride; CB-3025 HYDROCHLORIDE; ALANINE, 3-(p-(BIS(2-CHLOROETHYL)AMINO)PHENYL)-, MONOHYDROCHLORIDE, L-; L-Phenylalanine mustard hydrochloride; UNII-1VXP4V453T; DTXSID60872785

Frequently Asked Questions

What are the CAS number and molecular formula of Melphalan hydrochloride?

CAS 3223-07-2; molecular formula C13H19Cl3N2O2; molecular weight — g/mol.

What other names is Melphalan hydrochloride known by?

Melphalan hydrochloride, 3223-07-2, Melphalan HCl, Alkeran hydrochloride, CB 3025 hydrochloride, Evomela.

Is Melphalan hydrochloride classified as hazardous?

Hazard statements reported: H300, H310, H330, H317, H340.

What are the key physical properties of Melphalan hydrochloride?

Solubility: 95% ethanol <0.9 (mg/mL); Solubility: Methanol 2.8 - 5.6 (mg/mL); Solubility: Water 1.7 - 2.3 (mg/mL); Solubility: Chloroform <1 (mg/mL).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.