盐酸尼卡地平

Description

nicardipine hydrochloride · CAS 54527-84-3 · C26H30ClN3O6. UNII K5BC5011K3.

Identification

CAS Registry Number	54527-84-3
PubChem CID	41114
Molecular formula	C26H30ClN3O6
IUPAC name	5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride
UNII (FDA)	K5BC5011K3

Computed Descriptors

Molecular Weight	516.0
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	10
Exact Mass	515.1823134
Monoisotopic Mass	515.1823134
Topological Polar Surface Area	114
Heavy Atom Count	36
Formal Charge	0
Complexity	856

Physical description & handling notes

• 211.9 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Regulatory Status

GHS notification summary	2% (1 / 49)

GHS Hazard Classification

GHS notification summary	2% (1 / 49)
Reported hazard statements	H301 (89.8%), H311 (79.6%), H331 (79.6%)

Documented Uses

• Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
• A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
• Drugs used to cause dilation of the blood vessels.
• Dihydropyridines [CS]; Cytochrome P450 2C8 Inhibitors [MoA]; Dihydropyridine Calcium Channel Blocker [EPC]; Cytochrome P450 3A4 Inhibitors [MoA]; Calcium Channel Antagonists [MoA]; Cytochrome P450 2C19 Inhibitors [MoA]; Cytochrome P450 2D6 Inhibitors [MoA]

Synonyms

NICARDIPINE HYDROCHLORIDE; 54527-84-3; Nicardipine HCl; Loxen; Perdipine; Nicodel; Perdipina; YC-93; Vasonase; Cardene SR; Barizin; Cardepine; Dacarel; Lecibra; Lecibral; Lescodil

Frequently Asked Questions

What are the CAS number and molecular formula of nicardipine hydrochloride?

CAS 54527-84-3; molecular formula C26H30ClN3O6; molecular weight — g/mol.

What other names is nicardipine hydrochloride known by?

NICARDIPINE HYDROCHLORIDE, 54527-84-3, Nicardipine HCl, Loxen, Perdipine, Nicodel.

Is nicardipine hydrochloride classified as hazardous?

2% of GHS notifications report no hazard classification (1 of 49).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.