N,N-二乙基乙酰胺

Description

N,N-Diethylacetamide · CAS 685-91-6 · C6H13NO. UNII 6YO81D7ST6. Boiling Point: 185.5 °C; Melting Point: LESS THAN 20 °C; Flash Point: 170 °F.

Identification

CAS Registry Number	685-91-6
PubChem CID	12703
Molecular formula	C6H13NO
IUPAC name	N,N-diethylacetamide
UNII (FDA)	6YO81D7ST6

Computed Descriptors

Molecular Weight	115.17
XLogP3	0.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	2
Exact Mass	115.099714038
Monoisotopic Mass	115.099714038
Topological Polar Surface Area	20.3
Heavy Atom Count	8
Formal Charge	0

Physical & Chemical Properties

Boiling Point	185.5 °C
Melting Point	LESS THAN 20 °C
Flash Point	170 °F
Density	0.9130 @ 17 °C
Vapor Pressure	0.89 [mmHg]
Vapor Pressure	2 MM HG @ 35 °C
LogP	log Kow = 0.34
LogP	0.37

Physical description & handling notes

• Colorless liquid; [HSDB]
• Colorless liquid
• Faint odor
• Sol in water, alcohol; sol in all proportions in ether, acetone, benzene
• When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
• Index of refraction: 1.4374 @ 17.4 °C/4 °C

Regulatory Status

GHS notification summary	2.2% (1 / 46)

GHS Hazard Classification

GHS notification summary	2.2% (1 / 46)
Reported hazard statements	H302 (97.8%), H312 (87%), H315 (97.8%), H319 (97.8%), H332 (87%), H335 (87%)

Documented Uses

• Acetamide, N,N-diethyl-: ACTIVE
• DIETHYLACETAMIDE- AN EXAMPLE OF DRUG ABUSE.
• SOLVENTS WERE TESTED IN MICE FOR THEIR TOXICITY, CENTRAL NERVOUS SYSTEM PROFILE, AND ACTIVITY IN THE INCLINED SCREEN AND BALANCE ROD TESTS AFTER INTRAPERITONEAL ADMINISTRATION, PLUS THEIR INFLUENCE ON THE HEXABARBITONE SLEEPING TIME AND MUSCLE RELAXANT PROPERTIES ON THE ROTA-ROD AFTER ORAL ADMINISTRATION. N,N-DIETHYLACETAMIDE WAS RECOMMENDED NOT TO EXCEED A CONCENTRATION OF 0.3 IN DRUG SOLUTIONS AS SOLVENT FOR SCREENING PURPOSES.
• IN MICE, THE DISCREPANCY BETWEEN IN VITRO & IN VIVO LIVER ENZYME INHIBITION ACTIVITY MAY BE DUE TO OXIDATIVE N-DEALKYLATION OF N,N-DIETHYLACETAMIDE OCCURRING IN VIVO, FACILITATING THE INHIBITION.

Synonyms

N,N-DIETHYLACETAMIDE; 685-91-6; Acetamide, N,N-diethyl-; DTXSID9020459; Acetic acid, amide, N,N-diethyl; 6YO81D7ST6; NSC-101; DTXCID10459; RefChem:161180; 211-685-2; Diethylacetamide; N-Acetyldiethylamine; MFCD00009047; N,N-diethyl-acetamide; N,N-Diaethylacetamid; N,N-Diaethylacetamid [German]

Frequently Asked Questions

What are the CAS number and molecular formula of N,N-Diethylacetamide?

CAS 685-91-6; molecular formula C6H13NO; molecular weight — g/mol.

What other names is N,N-Diethylacetamide known by?

N,N-DIETHYLACETAMIDE, 685-91-6, Acetamide, N,N-diethyl-, DTXSID9020459, Acetic acid, amide, N,N-diethyl, 6YO81D7ST6.

Is N,N-Diethylacetamide classified as hazardous?

2.2% of GHS notifications report no hazard classification (1 of 46).

What are the key physical properties of N,N-Diethylacetamide?

Boiling Point: 185.5 °C; Melting Point: LESS THAN 20 °C; Flash Point: 170 °F; Density: 0.9130 @ 17 °C.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.