奈帕芬胺

Description

Nepafenac · CAS 78281-72-8 · C15H14N2O2. UNII 0J9L7J6V8C.

Identification

CAS Registry Number	78281-72-8
PubChem CID	151075
Molecular formula	C15H14N2O2
IUPAC name	2-(2-amino-3-benzoylphenyl)acetamide
UNII (FDA)	0J9L7J6V8C

Computed Descriptors

Molecular Weight	254.28
XLogP3	1.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Exact Mass	254.105527694
Monoisotopic Mass	254.105527694
Topological Polar Surface Area	86.2
Heavy Atom Count	19
Formal Charge	0

Physical description & handling notes

• Solid
• Low but quantifiable plasma concentrations of nepafenac and amfenac were observed in the majority of subjects 2 and 3 hours postdose, respectively, following bilateral topical ocular TID dosing of nepafenac ophthalmic suspension, 0.1%. The mean steady-state Cmax for nepafenac and for amfenac were 0.310 ± 0.104 ng/ml and 0.422 ± 0.121 ng/ml, respectively, following ocular administration.

GHS Hazard Classification

Reported hazard statements	H400 (92.9%)

Documented Uses

• For the treatment of pain and inflammation associated with cataract surgery.
• Breast Feeding; Lactation; Milk, Human; Analgesic Agents; Anti-inflammatory Agents, Nonsteroidal
• Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
• Mechanisms of Action [MoA] - Cyclooxygenase Inhibitors
• Chemical Structure [CS] - Anti-Inflammatory Agents, Non-Steroidal
• Established Pharmacologic Class [EPC] - Nonsteroidal Anti-inflammatory Drug

Synonyms

Nepafenac; 78281-72-8; 2-(2-Amino-3-benzoylphenyl)acetamide; Nevanac; 2-Amino-3-benzoylbenzeneacetamide; AHR-9434; Ilevro; AL-6515; nepafenaco; AL 6515; nepafenacum; DTXSID0048638; 0J9L7J6V8C; CHEBI:75922; 2-[2-amino-3-(benzoyl)phenyl]acetamide; DTXCID7028564

Frequently Asked Questions

What are the CAS number and molecular formula of Nepafenac?

CAS 78281-72-8; molecular formula C15H14N2O2; molecular weight — g/mol.

What other names is Nepafenac known by?

Nepafenac, 78281-72-8, 2-(2-Amino-3-benzoylphenyl)acetamide, Nevanac, 2-Amino-3-benzoylbenzeneacetamide, AHR-9434.

Is Nepafenac classified as hazardous?

Hazard statements reported: H400.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.