奈替米星

Description

Netilmicin · CAS 56391-56-1 · C21H41N5O7. UNII 4O5J85GJJB. Solubility: 100; LogP: -3.

Identification

CAS Registry Number	56391-56-1
PubChem CID	441306
Molecular formula	C21H41N5O7
IUPAC name	(2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4-amino-3-[[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-6-(ethylamino)-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol
UNII (FDA)	4O5J85GJJB

Computed Descriptors

Molecular Weight	475.6
XLogP3	-4.2
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	8
Exact Mass	475.30059866
Monoisotopic Mass	475.30059866
Topological Polar Surface Area	200
Heavy Atom Count	33
Formal Charge	0

Physical & Chemical Properties

Solubility	100
LogP	-3

Physical description & handling notes

• Specific optical rotation: +164 deg at 26 °C/D (3 in water)
• When heated to decomposition it emits acrid smoke and irritating fumes.
• 216.82 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
• 218.55 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Documented Uses

• For the treatment of bacteremia, septicaemia, respiratory tract infections, skin and soft-tissue infection, burns, wounds, and peri-operative infections caused by susceptible strains.
• Ophthalmological preparations > Anti-infective agents
• (1) Other specified conjunctivitis; (2) Infectious blepharitis
• Netilmicin is indicated in the treatment of biliary tract infections caused by susceptible organisms. /Included in US product labeling/
• Netilmicin is indicated in the treatment of bone and joint infections caused by susceptible organisms. /Included in US product labeling/
• Netilmicin is indicated in the treatment of central nervous system infections caused by susceptible organisms. /Included in US product labeling/

Synonyms

netilmicin; 1-N-Ethylsisomicin; 56391-56-1; Netilmicina; Netilmicine; Netilmicinum; Vectacin; Netillin; Netilyn; Netira; 1-N-Aethylsisomicin; Nettacin; 4O5J85GJJB; NSC-759586; DTXSID1048542; RefChem:165544

Frequently Asked Questions

What are the CAS number and molecular formula of Netilmicin?

CAS 56391-56-1; molecular formula C21H41N5O7; molecular weight — g/mol.

What other names is Netilmicin known by?

netilmicin, 1-N-Ethylsisomicin, 56391-56-1, Netilmicina, Netilmicine, Netilmicinum.

What are the key physical properties of Netilmicin?

Solubility: 100; LogP: -3.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.