N-氨甲酰-L-谷氨酸

Description

N-carbamyl-L-glutamic acid · CAS 1188-38-1 · C6H10N2O5. UNII 5L0HB4V1EW. LogP: -1.097.

Identification

CAS Registry Number	1188-38-1
PubChem CID	121396
Molecular formula	C6H10N2O5
IUPAC name	(2S)-2-(carbamoylamino)pentanedioic acid
UNII (FDA)	5L0HB4V1EW

Computed Descriptors

Molecular Weight	190.15
XLogP3	-2.4
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	190.05897142
Monoisotopic Mass	190.05897142
Topological Polar Surface Area	130
Heavy Atom Count	13
Formal Charge	0

Physical & Chemical Properties

LogP	-1.097

Physical description & handling notes

• Solid
• The median Tmax of Carbaglu was 3 hours (range: 2-4). The daily dose of carglumic acid ranges from 100 to 250 mg/kg and this does are normally adjusted to maintain normal plasma levels of ammonia.

GHS Hazard Classification

Reported hazard statements	H302 (100%), H315 (100%), H319 (100%), H335 (100%)

Documented Uses

• For the treatment of acute and chronic hyperammonaemia in patients with N-acetylglutamate synthase (NAGS) deficiency. This enzyme is an important component of the urea cycle to prevent build up of neurotoxic ammonium in the blood.
• Carglumic acid is an orphan drug and a derivative of N-acetylglutamate that activates the first enzyme in the urea cycle that is responsible for removal and detoxification of ammonia, making this drug a valuable agent for therapy of hyperammonemia caused by rare forms of urea cycle defects. Clinical experience with carglumic acid is limited, but it has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury.
• Take before a meal. Take carglumic acid right before eating.
• Take with plain water. Carglumic acid tablets are dispersed in water to produce an oral suspension and should not be swallowed whole.
• Established Pharmacologic Class [EPC] - Carbamoyl Phosphate Synthetase 1 Activator
• Mechanisms of Action [MoA] - Carbamoyl Phosphate Synthetase 1 Activators

Synonyms

Carglumic acid; 1188-38-1; N-Carbamyl-L-glutamic acid; Carbaglu; N-Carbamoyl-L-glutamic acid; (2S)-2-(carbamoylamino)pentanedioic acid; Ureidoglutaric acid; Carbamylglutamic acid; Carbamino-L-glutamic acid; L-N-Carbamoylglutamic acid; acido carglumico; acide carglumique; L-Glutamic acid, N-(aminocarbonyl)-; DTXSID7046706; acidum carglumicum; 5L0HB4V1EW

Frequently Asked Questions

What are the CAS number and molecular formula of N-carbamyl-L-glutamic acid?

CAS 1188-38-1; molecular formula C6H10N2O5; molecular weight — g/mol.

What other names is N-carbamyl-L-glutamic acid known by?

Carglumic acid, 1188-38-1, N-Carbamyl-L-glutamic acid, Carbaglu, N-Carbamoyl-L-glutamic acid, (2S)-2-(carbamoylamino)pentanedioic acid.

Is N-carbamyl-L-glutamic acid classified as hazardous?

Hazard statements reported: H302, H315, H319, H335.

What are the key physical properties of N-carbamyl-L-glutamic acid?

LogP: -1.097.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.