二酒石酸尼古丁二水合物

Description

Nicotine ditartrate dihydrate · CAS 6019-06-3 · C18H30N2O14. UNII R7M676M8YV. European Pharmacopoeia monograph.

Identification

CAS Registry Number	6019-06-3
PubChem CID	2735102
Molecular formula	C18H30N2O14
IUPAC name	bis((2R,3R)-2,3-dihydroxybutanedioic acid);3-[(2S)-1-methylpyrrolidin-2-yl]pyridine;dihydrate
UNII (FDA)	R7M676M8YV
Pharmacopoeial monograph	European Pharmacopoeia monograph

Computed Descriptors

Molecular Weight	498.4
Hydrogen Bond Donor Count	10
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	7
Exact Mass	498.16970364
Monoisotopic Mass	498.16970364
Topological Polar Surface Area	248
Heavy Atom Count	34
Formal Charge	0
Complexity	281

GHS Hazard Classification

Reported hazard statements	H301, H331 (100%), H310 (100%), H372 (100%)

Documented Uses

• Substances that facilitate the cessation of tobacco smoking.
• Agents that mimic neural transmission by stimulation of the nicotinic receptors on postganglionic autonomic neurons. Drugs that indirectly augment ganglionic transmission by increasing the release or slowing the breakdown of acetylcholine or by non-nicotinic effects on postganglionic neurons are not included here nor are the nonspecific cholinergic agonists.
• Drugs that bind to and activate nicotinic cholinergic receptors (RECEPTORS, NICOTINIC). Nicotinic agonists act at postganglionic nicotinic receptors, at neuroeffector junctions in the peripheral nervous system, and at nicotinic receptors in the central nervous system. Agents that function as neuromuscular depolarizing blocking agents are included here because they activate nicotinic receptors, although they are used clinically to block nicotinic transmission.

Synonyms

Nicotine bitartrate; 6019-06-3; Nicotine bitartrate dihydrate; R7M676M8YV; Nicotine acid tartrate dihydrate; Nicotine (as bitartrate); 3-((2S)-1-Methyl-2-pyrrolidinyl)pyridine, (2R,3R)-2,3-dihydroxybutanedioate (1:2), dihydrate; Pyridine, 3-((2S)-1-methyl-2-pyrrolidinyl)-, (2R,3R)-2,3-dihydroxybutanedioate, hydrate (1:2:2); Nicotine hydrogen-l-tartrate; RefChem:165741; NSC-97238; NICOTINE DITARTRATE DIHYDRATE; Nicotine bitartrate [USAN]; S-(-)-Nicotine Ditartrate Dihydrate; Nicotine bitartrate [WHO-DD]; UNII-R7M676M8YV

Frequently Asked Questions

What are the CAS number and molecular formula of Nicotine ditartrate dihydrate?

CAS 6019-06-3; molecular formula C18H30N2O14; molecular weight — g/mol.

What other names is Nicotine ditartrate dihydrate known by?

Nicotine bitartrate, 6019-06-3, Nicotine bitartrate dihydrate, R7M676M8YV, Nicotine acid tartrate dihydrate, Nicotine (as bitartrate).

Is Nicotine ditartrate dihydrate classified as hazardous?

Hazard statements reported: H301, H331, H310, H372.

Does Nicotine ditartrate dihydrate have a pharmacopoeial monograph?

Yes — a monograph exists in the European Pharmacopoeia (Ph. Eur.).

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.