Nicardipine

Description

Nicardipine · CAS 55985-32-5 · C26H29N3O6. UNII CZ5312222S. Melting Point: 136-138 °C; Melting Point: 136 - 138 °C; Solubility: 2.2.

Identification

CAS Registry Number	55985-32-5
PubChem CID	4474
Molecular formula	C26H29N3O6
IUPAC name	5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
UNII (FDA)	CZ5312222S

Computed Descriptors

Molecular Weight	479.5
XLogP3	3.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	10
Exact Mass	479.20563565
Monoisotopic Mass	479.20563565
Topological Polar Surface Area	114
Heavy Atom Count	35
Formal Charge	0

Physical & Chemical Properties

Melting Point	136-138 °C
Melting Point	136 - 138 °C
Solubility	2.2
Solubility	2.47e-03 g/L
LogP	3.82
LogP	3.6
LogP	3.67

Physical description & handling notes

• Solid
• 211.2 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID9046992]
• 208.8 Ų [M]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID9046992]
• 213.0 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID9046992]
• 212.6 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID9046992]
• 214.2 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID9046992]

GHS Hazard Classification

Reported hazard statements	H302 (100%)

Documented Uses

• Used for the management of patients with chronic stable angina and for the treatment of hypertension.
• Nicardipine is a second generation calcium channel blocker used in the treatment of hypertension and stable angina pectoris. Nicardipene therapy has been associated with a low rate of transient serum enzyme elevations, but has not been linked convincingly to instances of clinically apparent liver injury with jaundice.
• Breast Feeding; Lactation; Milk, Human; Antihypertensive Agents; Calcium Channel Blockers; Vasodilator Agents
• Take with or without food. The absorption is unaffected by food.
• Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
• A class of drugs that act by selective inhibition of calcium influx through cellular membranes.

Synonyms

nicardipine; 55985-32-5; Nicardipino; Nicardipinum; Perpidine; Nicardipine (stn); CHEBI:7550; DTXSID6023363; CZ5312222S; DTXCID903363; nicardipina; LA, Nicardipine; RefChem:56587; Hydrochloride, Nicardipine; C08CA04; 259-932-3

Frequently Asked Questions

What are the CAS number and molecular formula of Nicardipine?

CAS 55985-32-5; molecular formula C26H29N3O6; molecular weight — g/mol.

What other names is Nicardipine known by?

nicardipine, 55985-32-5, Nicardipino, Nicardipinum, Perpidine, Nicardipine (stn).

Is Nicardipine classified as hazardous?

Hazard statements reported: H302.

What are the key physical properties of Nicardipine?

Melting Point: 136-138 °C; Melting Point: 136 - 138 °C; Solubility: 2.2; Solubility: 2.47e-03 g/L.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.