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Description

Nolatrexed dihydrochloride · CAS 152946-68-4 · C14H14Cl2N4OS. UNII 1XA69O733O.

Identification

CAS Registry Number	152946-68-4
PubChem CID	135409535
Molecular formula	C14H14Cl2N4OS
IUPAC name	2-amino-6-methyl-5-pyridin-4-ylsulfanyl-3H-quinazolin-4-one;dihydrochloride
UNII (FDA)	1XA69O733O

Computed Descriptors

Molecular Weight	357.3
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	356.0265376
Monoisotopic Mass	356.0265376
Topological Polar Surface Area	106
Heavy Atom Count	22
Formal Charge	0
Complexity	408

GHS Hazard Classification

Reported hazard statements	H341 (100%), H361 (97.9%)

Documented Uses

• Antimetabolites that are useful in cancer chemotherapy.
• Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
• Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)

Synonyms

Nolatrexed dihydrochloride; 152946-68-4; Thymitaq; AG 337; AG-337; DTXSID4046810; 1XA69O733O; AG337; 4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio)-, dihydrochloride; DTXCID2026810; 3,4-Dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)quinazoline dihydrochloride; Nolatrexed Hydrochloride; RefChem:927872; 3,4-dihydro-2-amino-6-methyl-4-oxy-5-(4-pyridylthio)-quinazoline dihydrochloride; Nolatrexed HCl; C14H14Cl2N4OS

Frequently Asked Questions

What are the CAS number and molecular formula of Nolatrexed dihydrochloride?

CAS 152946-68-4; molecular formula C14H14Cl2N4OS; molecular weight — g/mol.

What other names is Nolatrexed dihydrochloride known by?

Nolatrexed dihydrochloride, 152946-68-4, Thymitaq, AG 337, AG-337, DTXSID4046810.

Is Nolatrexed dihydrochloride classified as hazardous?

Hazard statements reported: H341, H361.

Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.